UMMS Affiliation
Department of Pediatrics
Publication Date
1998-12-16
Document Type
Article
Subjects
Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Child, Preschool; *Disease Transmission, Vertical; Drug Therapy, Combination; HIV-1; Humans; Infant; Infant, Newborn; Viremia; *Virus Replication
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
Source
J Virol. 1999 Jan;73(1):362-7.
Journal/Book/Conference Title
Journal of virology
Related Resources
PubMed ID
9847340
Repository Citation
Luzuriaga K, Wu H, McManus MM, Britto P, Borkowsky W, Burchett SK, Smith B, Mofenson LM, Sullivan JL. (1998). Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. Open Access Publications by UMMS Authors. Retrieved from https://escholarship.umassmed.edu/oapubs/1540