Department of Pediatrics
Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Child, Preschool; *Disease Transmission, Vertical; Drug Therapy, Combination; HIV-1; Humans; Infant; Infant, Newborn; Viremia; *Virus Replication
Life Sciences | Medicine and Health Sciences
Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
J Virol. 1999 Jan;73(1):362-7.
Journal of virology
Luzuriaga, Katherine; Wu, Hulin; McManus, Margaret M.; Britto, Paula; Borkowsky, William; Burchett, Sandra K.; Smith, Betsy; Mofenson, Lynne M.; and Sullivan, John L., "Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants" (1998). Open Access Articles. 1540.