Department of Pediatrics
Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Child, Preschool; *Disease Transmission, Vertical; Drug Therapy, Combination; HIV-1; Humans; Infant; Infant, Newborn; Viremia; *Virus Replication
Life Sciences | Medicine and Health Sciences
Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
J Virol. 1999 Jan;73(1):362-7.
Journal of virology
Luzuriaga K, Wu H, McManus MM, Britto P, Borkowsky W, Burchett SK, Smith B, Mofenson LM, Sullivan JL. (1998). Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. Open Access Publications by UMMS Authors. Retrieved from https://escholarship.umassmed.edu/oapubs/1540