UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Program in Cell Dynamics

Publication Date


Document Type



Animals; Humans; *RNA Interference; RNA Processing, Post-Transcriptional; RNA, Messenger


Life Sciences | Medicine and Health Sciences


The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.

DOI of Published Version



Mol Biol Cell. 2004 Feb;15(2):407-10. Epub 2003 Dec 2. Link to article on publisher's site

Journal/Book/Conference Title

Molecular biology of the cell

Related Resources

Link to Article in PubMed

PubMed ID




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