UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology; Program in Cell Dynamics
Publication Date
2003-12-06
Document Type
Article
Subjects
Animals; Humans; *RNA Interference; RNA Processing, Post-Transcriptional; RNA, Messenger
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.
DOI of Published Version
10.1091/mbc.E03-10-0726
Source
Mol Biol Cell. 2004 Feb;15(2):407-10. Epub 2003 Dec 2. Link to article on publisher's site
Journal/Book/Conference Title
Molecular biology of the cell
Related Resources
PubMed ID
14657237
Repository Citation
Pederson, Thoru, "RNA interference and mRNA silencing, 2004: how far will they reach" (2003). Open Access Articles. 1387.
https://escholarship.umassmed.edu/oapubs/1387