Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis
Authors
Savarese, Todd M.Strohsnitter, William C.
Low, Hoi Pang
Liu, Qin
Baik, Inkyung
Okulicz, William C.
Chelmow, David P.
Lagiou, Pagona
Quesenberry, Peter J.
Noller, Kenneth L.
Hsieh, Chung-Cheng
UMass Chan Affiliations
Department of PhysiologyDepartment of Neurology
Department of Cancer Biology
Cancer Center
Document Type
Journal ArticlePublication Date
2007-05-16Keywords
Antigens, CDBreast Neoplasms
Cell Division
Erythroid Progenitor Cells
Female
Fetal Blood
Growth Substances
Hematopoietic Stem Cells
Hormones
Humans
Infant, Newborn
Insulin-Like Growth Factor I
Pregnancy
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
INTRODUCTION: Prenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential. METHODS: We analyzed cord blood samples from 289 deliveries. Levels of hormones and growth factors were correlated with concentrations of stem cell and progenitor populations (CD34+ cells, CD34+CD38- cells, CD34+c-kit+ cells, and granulocyte-macrophage colony-forming units). Changes in stem cell concentration associated with each standard deviation change in mitogens and the associated 95% confidence intervals were calculated from multiple regression analysis. RESULTS: Cord blood plasma levels of insulin-like growth factor-1 (IGF-1) were strongly correlated with all the hematopoietic stem and progenitor concentrations examined (one standard-deviation increase in IGF-1 being associated with a 15-19% increase in stem/progenitor concentrations, all P < 0.02). Estriol and insulin-like growth factor binding protein-3 levels were positively and significantly correlated with some of these cell populations. Sex hormone-binding globulin levels were negatively correlated with these stem/progenitor pools. These relationships were stronger in Caucasians and Hispanics and were weaker or not present in Asian-Americans and African-Americans. CONCLUSION: Our data support the concept that in utero mitogens may drive the expansion of stem cell populations. The correlations with IGF-1 and estrogen are noteworthy, as both are crucial for mammary gland development.Source
Breast Cancer Res. 2007;9(3):R29. Link to article on publisher's siteDOI
10.1186/bcr1674Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38380PubMed ID
17501995Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1186/bcr1674