UMMS Affiliation

Neuropsychiatric Sciences Program

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Document Type



Aggression; Animals; Arginine Vasopressin; Behavior, Animal; Cricetinae; Fluoxetine; Hypothalamus, Anterior; Male; Mesocricetus; Microinjections; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Vasopressin; Serotonin; Serotonin Uptake Inhibitors; Vasoconstrictor Agents


Life Sciences | Medicine and Health Sciences


Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.


J Neurosci. 1997 Jun 1;17(11):4331-40.

Journal/Book/Conference Title

The Journal of neuroscience : the official journal of the Society for Neuroscience

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Link to Article in PubMed

PubMed ID