Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters
Authors
Ferris, Craig F.Melloni, Richard H.
Koppel, Gary A.
Perry, Kenneth W.
Fuller, Ray W.
Yvon, Delville
UMass Chan Affiliations
Neuropsychiatric Sciences ProgramDocument Type
Journal ArticlePublication Date
1997-06-01Keywords
AggressionAnimals
Arginine Vasopressin
Behavior, Animal
Cricetinae
Fluoxetine
Hypothalamus, Anterior
Male
Mesocricetus
Microinjections
Receptor, Serotonin, 5-HT1B
Receptors, Serotonin
Receptors, Vasopressin
Serotonin
Serotonin Uptake Inhibitors
Vasoconstrictor Agents
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.Source
J Neurosci. 1997 Jun 1;17(11):4331-40.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38312PubMed ID
9151749Related Resources
Link to Article in PubMedCollections
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