Document Type
Journal ArticlePublication Date
1990-02-01Keywords
AdultAntigen-Presenting Cells
Antigens, CD4
Cell Separation
Dinoprostone
Humans
Interleukin-1
Middle Aged
Monocytes
Plasminogen Activators
T-Lymphocytes
Tetanus Toxoid
Tumor Necrosis Factor-alpha
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Although CD4 antigen is expressed on monocytes (MO), its functional role is uncharacterized. In this study, isolated human MO were separated into CD4+ and CD4- MO subsets and assessed for presentation of tetanus toxoid. The CD4- MO subset had decreased antigen presenting cell (APC) capacity as well as increased PGE2 production when compared to the CD4+ MO subset. Addition of a cyclo-oxygenase inhibitor (Indomethacin) did not restore the CD4- MO subset's APC capacity to that of the similarly treated CD4+ MO subset, eliminating differential PGE2 production as the primary cause of differential APC capacity. Production of monokines such as IL-1 and plasminogen activator, which affect APC capacity, was similar in the CD4 MO subsets. However, tumor necrosis factor (TNF) production (IFN gamma plus MDP-induced) of the CD4+ MO subset was slightly greater than that of the CD4- MO. CD4- MO's lower APC capacity is not totally explained by their differential IL-1, TNF, or PGE2 production.Source
J Leukoc Biol. 1990 Feb;47(2):111-20.
DOI
10.1002/jlb.47.2.111Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38278PubMed ID
2303746Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/jlb.47.2.111