Title
Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption
UMMS Affiliation
Department of Anatomy
Publication Date
1987-11-01
Document Type
Article
Subjects
Acid Phosphatase; Alveolar Process; Animals; *Bone Resorption; Dental Sac; Dogs; Histocytochemistry; Osteoclasts; Tartrates; *Tooth Eruption
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Tartrate-resistant acid phosphatase (TRAP) has been used as a cytochemical marker for the cell mediators of bone resorption, osteoclasts and their mononuclear precursors. We have applied a cytochemical method for TRAP to study the dependence of the osteoclast-mediated bone resorption of tooth eruption on the dental follicle, a connective tissue investment of the developing tooth, by analyzing the TRAP activity of mononuclear cells in the dental follicle before and during pre-molar eruption in dogs. The percentage of TRAP-positive monocyte cells increases until mid-eruption, slightly preceding a previously demonstrated rise in numbers of osteoclasts on adjacent bone surfaces. These data suggest an ontogenetic relationship between follicular mononuclear cells and osteoclasts on adjacent alveolar bone surfaces during tooth eruption. However, because TRAP occurs in other tissues and is not an exclusive indicator of pre-osteoclasts, proof of their relationship will have to await application of more definitive techniques.
DOI of Published Version
10.1177/35.11.3655324
Source
J Histochem Cytochem. 1987 Nov;35(11):1227-30.
Journal/Book/Conference Title
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Related Resources
PubMed ID
3655324
Repository Citation
Marks, Sandy C. and Grolman, My-Lan, "Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption" (1987). Open Access Articles. 1079.
https://escholarship.umassmed.edu/oapubs/1079