Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2018

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The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology, Yu Fu, Yujing Yang, Han Zhang, Gwen Farley, Junling Wang, Kaycee A. Quarles, Zhiping Weng, and Phillip D. Zamore

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Research evaluation support services in biomedical libraries, Karen Elizabeth Gutzman, Michael E. Bales, Christopher W. Belter, Thane Chambers, Liza Chan, Kristi L. Holmes, Ya-Ling Lu, Lisa A. Palmer, Rebecca Reznik-Zellen, Cathy C. Sarli, Amy M. Suiter, and Terrie R. Wheeler

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo, Matthew R. Hassler, Anton A. Turanov, Julia F. Alterman, Reka A. Haraszti, Andrew H. Coles, Maire F. Osborn, Dimas Echeverria, Mehran Nikan, William E. Salomon, Loic Roux, Bruno M. D. C. Godinho, Sarah M. Davis, David V. Morrissey, Phillip D. Zamore, S. Ananth Karumanchi, Melissa J. Moore, Neil Aronin, and Anastasia Khvorova

Publications from 2017

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Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study, Adeyinka Adejumo, Samson Alliu, Tokunbo Opeyemi Ajayi, Kelechi Lauretta Adejumo, Oluwole Muyiwa Adegbala, Nnaemeka Egbuna Onyeakusi, Akintunde Micheal Akinjero, Modupeoluwa Durojaiye, and Terence N. Bukong

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Defining the 5 and 3 landscape of the Drosophila transcriptome with Exo-seq and RNaseH-seq, Shaked Afik, Osnat Bartok, Maxim N. Artyomov, Alexander A. Shishkin, Sabah Kadri, Mor Hanan, Xiaopeng Zhu, Manuel Garber, and Sebastian Kadener

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Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery, Jianzhong Ai, Jia Li, Dominic J. Gessler, Qin Su, Qiang Wei, Hong Li, and Guangping Gao

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Risks of PEG tube placement in patients with cirrhosis-associated ascites, Yasir Al-Abboodi, Ali Ridha, Matthew J. Fasullo, and Tarek H. Naguib

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Evaluation of the impact of a prescribing guideline on the use of intraoperative dexmedetomidine at a tertiary academic medical center, Abdullah M. Alhammad, Nour A. Baghdady, Rachel A. Mullin, and Bonnie C. Greenwood

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A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics, Julia F. Alterman, Andrew H. Coles, Lauren M. Hall, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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Staying afloat in a sea of information: Point-of-care resources, Rebecca Andrews, Neil Mehta, Jack Maypole, and Stephen A. Martin

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FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia, Ami Ashar-Patel, Yasin Kaymaz, Augustine Rajakumar, Jeffrey A. Bailey, S. Ananth Karumanchi, and Melissa J. Moore

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Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity, A. M. Ashique, L. S. Hart, C. D. L. Thomas, J. G. Clement, P. Pivonka, Yasmin Carter, D. D. Mousseau, and D. M. L. Cooper

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Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires, Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Nucleosomes influence multiple steps during replication initiation, Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A. Belsky, David M. MacAlpine, Craig L. Peterson, and Stephen P. Bell

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A National CERA Study of the Use of Laborists in Family Medicine Residency Training, Robert A. Baldor, Christine Chang Pecci, Gerardo Moreno, Virginia Van Duyne, and Stacy E. Potts

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Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior, Navonil Banerjee, Raja Bhattacharya, Michael Gorczyca, Kevin M. Collins, and Michael M. Francis

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BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, and Javier Gordon Ogembo

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Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit, Belinda Barbagallo, Alison Philbrook, Denis Touroutine, Navonil Banerjee, Devyn Oliver, Christopher M. Lambert, and Michael M. Francis

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Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J. Duenas-Decamp, Paul R. Clapham, Karin J. Metzner, Huldrych F. Gunthard, and Alexandra Trkola

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A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma, Afshin Beheshti, Charles Vanderburg, J. Tyson McDonald, Charusheila Ramkumar, Tatenda Kadungure, Hong Zhang, Ronald B. Gartenhaus, and Andrew M. Evens

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HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins, Damien Bertheloot and Eicke Latz

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Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans, Cassandra R. Blanchette, Andrea Thackeray, Paola N. Perrat, Siegfried Hekimi, and Claire Y. Benard

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Virtual Patient Technology: Engaging Primary Care in Quality Improvement Innovations, Amanda C. Blok, Christine N. May, Rajani S. Sadasivam, and Thomas K. Houston

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The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis, Cordula M. Boehm, Samson Obado, Catarina Gadelha, Alexandra Kaupisch, Paul T. Manna, Gwyn W. Gould, Mary Munson, Brian T. Chait, Michael P. Rout, and Mark C. Field

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"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report, Cesar Boggiano, Katrin Eichelberg, Lakshmi Ramachandra, Jaqueline Shea, Lalita Ramakrishnan, Samuel M. Behar, Joel D. Ernst, Steven A. Porcelli, Markus Maeurer, and Hardy Kornfeld

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Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1, Erik J. Boll, Jorge Ayala-Lujan, Rose L. Szabady, Christopher Louissaint, Rachel Z. Smith, Karen A. Krogfelt, James P. Nataro, Fernando Ruiz-Perez, and Beth A. McCormick

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Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro, Gabriel A. Bonaterra, David F. Driscoll, Hans Schwarzbach, and Ralf Kinscherf

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A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival, Elias Bou Samra, Geraldine Buhagiar-Labarchede, Christelle Machon, Jerome Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, and Mounira Amor-Gueret

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A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes, Julianna Bozler, Balint Z. Kacsoh, Hao Chen, William E. Theurkauf, Zhiping Weng, and Giovanni Bosco

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Soluble Uric Acid Activates the NLRP3 Inflammasome, Tarcio Teodoro Braga, Maria Fernanda Forni, Matheus Correa-Costa, Rodrigo Nalio Ramos, Jose Alexandre Barbuto, Paola Branco, Angela Castoldi, Meire Ioshie Hiyane, Mariana Rodrigues Davanso, Eicke Latz, Bernardo S. Franklin, Alicia J. Kowaltowski, and Niels Olsen Saraiva Camara

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A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder, James Douglas Bremner, Sanskriti Mishra, Carolina Campanella, Majid Shah, Nicole Kasher, Sarah Evans, Negar Fani, Amit Jasvant Shah, Collin Reiff, Lori L. Davis, Viola Vaccarino, and James F. Carmody

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Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii, Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, and Maureen Wirschell

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IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium, Jason M. Brown, Tyler Picariello, Deborah A. Cochran, George B. Witman, and Karl Lechtreck

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Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes, Ange-Line Bruel, Thibaut Eguether, Gregory J. Pazour, and Christel Thauvin-Robinet

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Donor Diabetes and Prolonged Cold Ischemia Time Synergistically Increase the Risk of Graft Failure After Liver Transplantation, Isabel M. A. Bruggenwirth, Natasha H. Dolgin, Robert J. Porte, Adel Bozorgzadeh, and Paulo N.A. Martins

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Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial, Gerd R. Burmester, William F. Rigby, Ronald F. van Vollenhoven, Jonathan Kay, Andrea Rubbert-Roth, Ricardo Blanco, Alysha Kadva, and Sophie Dimonaco

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Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial, Andrew Busch, Erin M. Tooley, Shira Dunsiger, Elizabeth A. Chattillion, John Fani Srour, Sherry L. Pagoto, Christopher W. Kahler, and Belinda Borrelli

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Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis, Carmelo Carmona-Rivera, Paul R. Thompson, and Mariana J. Kaplan

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Randomized Controlled Study of a Remote Flipped Classroom Neuro-otology Curriculum, Frederick Robert Carrick, Mahera Abdulrahman, Ahmed Hankir, Maksim Zayaruzny, Kinda Najem, Palita Lungchukiet, and Roger A. Edwards

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Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown, Laura Cau, Valerie Pendaries, Emeline Lhuillier, Paul R. Thompson, Guy Serre, Hidenari Takahara, Marie-Claire Mechin, and Michel Simon

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue, Carly T. Cederquist, Claudia Lentucci, Camila Martinez Calejman, Vanessa Hayashi, Joseph Orofino, David A. Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, and Valentina Perissi

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High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection, Alper Celik, Richard E. Baker, Feng He, and Allan Jacobson

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A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification, Can Cenik, Hon Nian Chua, Guramrit Singh, Abdalla Akef, Michael P. Snyder, Alexander F. Palazzo, Melissa J. Moore, and Frederick P. Roth

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Augmenting the anisotropic network model with torsional potentials improves PATH performance, enabling detailed comparison with experimental rate data, Srinivas Niranj Chandrasekaran and Charles W. Carter Jr

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An SMC-like protein binds and regulates Caenorhabditis elegans condensins, Lucy Fang-I Chao, Meha Singh, James Thompson, John R. Yates 3rd, and Kirsten A. Hagstrom

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Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis, Catherine Y. Cheng, Nuria M. Martinez, Kim West, Hardy Kornfeld, and Amit Singhal

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Cdc6 contributes to abrogating the G1 checkpoint under hypoxic conditions in HPV E7 expressing cells, Hanxiang Chen, Qishu Zhang, Lijun Qiao, Xueli Fan, Weifang Zhang, Weiming Zhao, and Jason J. Chen

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HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans, Huan-Da Chen, Raffi V. Aroian, and Chang-Shi Chen

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Ranking Medical Terms to Support Expansion of Lay Language Resources for Patient Comprehension of Electronic Health Record Notes: Adapted Distant Supervision Approach, Jinying Chen, Abhyuday N. Jagannatha, Samah J. Fodeh, and Hong Yu

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The prevalence and risk factors of preterm small-for-gestational-age infants: a population-based retrospective cohort study in rural Chinese population, Shi Chen, Rong Zhu, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang, Bill Q. Lian, Chengsheng Yan, Jianqiang Li, Qing Wang, Shi-Kun Zhang, and Hui Pan

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Establishing a Research Agenda for Understanding the Role and Impact of Mental Health Peer Specialists, Matthew Chinman, D. Keith. McInnes, Susan Eisen, Marsha Langer Ellison, Marianne Farkas, Moe Armstrong, and Sandra G. Resnick

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Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials, Paul P. Christopher, Paul S. Appelbaum, Debbie Truong, Karen Albert, Louise S. Maranda, and Charles W. Lidz

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21, B. Colleoni, S. Paternot, J. M. Pita, X. Bisteau, K. Coulonval, Roger J. Davis, E. Raspe, and P. P. Roger

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The 2016 Model of the Clinical Practice of Emergency Medicine, Francis L. Counselman, Kavita Babu, Mary Ann. Edens, Diane L. Gorgas, Cherri Hobgood, Catherine A. Marco, Eric Katz, Kevin Rodgers, Leonard A. Stallings, Michael C. Wadman, Michael S. Beeson, Julia N. Keehbauch, and American Board of Emergency Medicine

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Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling, Chunhua Dai, Yan Hang, Alena Shostak, Greg Poffenberger, Nathaniel Hart, Nripesh Prasad, Neil Phillips, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Seung K. Kim, and Alvin C. Powers

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Multiple fixed drug eruption to minocycline at sites of healed burn and zoster: An interesting case of locus minoris resistentiae, Renata Dalla Costa, Connie Yihan Yang, Molly Stout, Daniela Kroshinsky, and Arianne Shadi Kourosh

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Effect of transcription factor resource sharing on gene expression noise, Dipjyoti Das, Supravat Dey, Robert C. Brewster, and Sandeep Choubey (PLoS computational biology, 4-17-2017)

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Melanoma mystery, Roger J. Davis

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Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis, Michael A. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong. Park, Jarukit E. Long, Cara C. Boutte, Eric J. Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M. Fortune, Christopher M. Sassetti, and Thomas R. Ioerger

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Statistical analysis of genetic interactions in Tn-Seq data, Michael A. DeJesus, Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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Mechanism of ribosome rescue by ArfA and RF2, Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, and Andrei A. Korostelev

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Diagnostic performance and optimal cut-off scores of the Massachusetts youth screening instrument-second version in a sample of Swiss youths in welfare and juvenile justice institutions, Claudia Dolitzsch, Laura E. W. Leenarts, Klaus Schmeck, Jorg M. Fegert, Thomas Grisso, and Marc Schmid

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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates, Joshua C. Doloff, Dale L. Greiner, and Daniel G. Anderson

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Evidence of potential bias in a comparison of beta blockers and calcium channel blockers in patients with chronic obstructive pulmonary disease and acute coronary syndrome: results of a multinational study, Yaa-Hui Dong, Matthew Alcusky, Vittorio Maio, Jun Liu, Mengdan Liu, Li-Chiu Wu, Chia-Hsuin Chang, Mei-Shu Lai, and Joshua J. Gagne

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An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5, Ly-Sha Ee, Kurtis N. McCannell, Yang Tang, Nancy Fernandes, W. Rod Hardy, Michael R. Green, Feixia Chu, and Thomas G. Fazzio

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Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

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A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events, Nathaniel Erskine, Hoang Tran, Len L. Levin, Christine M. Ulbricht, Joyce D. Fingeroth, Catarina I. Kiefe, Robert J. Goldberg, and Sonal Singh

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A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

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Teens, Tweets, and Tanning Beds: Rethinking the Use of Social Media for Skin Cancer Prevention, Ashley E. Falzone, Claire D. Brindis, Mary-Margaret Chren, Alexandra Junn, Sherry L. Pagoto, Mackenzie Wehner, and Eleni Linos

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Microscopic Colitis After Fecal Microbiota Transplant, Matthew J. Fasullo, Yasir Al-Azzawi, and Jeffrey Abergel

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Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy, Timothy P. Fitzgibbons, Yvonne J. K. Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah T. Bote, Tejen Shah, Sumita Sinha, Robert E. Gerszten, John F. Keaney Jr., Michael R. Zile, and Gerard P. Aurigemma

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Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

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Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization, G. G. Fouda, J. Eudailey, E. L. Kunz, J. D. Amos, B. E. Liebl, J. Himes, F. Boakye-Agyeman, K. Beck, Anthony J. Michaels, M. Cohen-Wolkowiez, B. F. Haynes, Keith A. Reimann, and S. R. Permar

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Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States, Patricia D. Franklin, Hermes Miozzari, Panayiotis Christofilopoulos, Pierre Hoffmeyer, David C. Ayers, and Anne Lubbeke

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alpha-Gal Nanoparticles in Wound and Burn Healing Acceleration, Uri Galili

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A paradigm shift for socioeconomic justice and health: from focusing on inequalities to aiming at sustainable equity, Juan E. Garay and David E. Chiriboga

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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis, Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, and Junying Yuan

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Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation, Josephine R. Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, and Mark J. Shlomchik

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Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy, Heather L. Gray-Edwards, Xuntian Jiang, Ashley N. Randle, Amanda R. Taylor, Taylor L. Voss, Aime K. Johnson, Victoria J. McCurdy, Miguel Sena-Esteves, Daniel S. Ory, and Douglas R. Martin

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, Evelyn V. Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences, Patrick A. Guerra and Steven M. Reppert

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Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves

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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay, Justin Hall, Douglas T. Golenbock, and Eicke Latz

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Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies, Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew H. Fischer, Peter L. Jones, and Jeanne B. Lawrence

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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System, Reka A. Haraszti, Andrew H. Coles, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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5-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo, Reka A. Haraszti, Loic Roux, Andrew H. Coles, Anton A. Turanov, Julia F. Alterman, Dimas Echeverria, Bruno M. D. C. Godinho, Neil Aronin, and Anastasia Khvorova

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Sex differences in gout characteristics: tailoring care for women and men, Leslie R. Harrold, Carol J. Etzel, Allan Gibofsky, Joel Kremer, Michael H. Pillinger, Kenneth G. Saag, Naomi Schlesinger, Robert Terkeltaub, Vanessa Cox, and Jeffrey D. Greenberg

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Impact of rituximab on patient-reported outcomes in patients with rheumatoid arthritis from the US Corrona Registry, Leslie R. Harrold, Ani John, Jennie Best, Steve Zlotnick, Chitra Karki, YouFu Li, Jeffrey D. Greenberg, and Joel M. Kremer

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Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis, Leslie R. Harrold, Ani John, George W. Reed, Tmirah Haselkorn, Chitra Karki, YouFu Li, Jennie Best, Steve Zlotnick, Joel M. Kremer, and Jeffrey D. Greenberg

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Health Evaluation and Referral Assistant: A Randomized Controlled Trial of a Web-Based Screening, Brief Intervention, and Referral to Treatment System to Reduce Risky Alcohol Use Among Emergency Department Patients, Brianna L. Haskins, Rachel Davis-Martin, Beau Abar, Brigitte M. Baumann, Tina Harralson, and Edwin D. Boudreaux

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Fluoroscopic imaging overestimates the screw tip to subchondral bone distance in a cadaveric model of slipped capital femoral epiphysis, Michael J. Heffernan, B. Snyder, H. Zhou, and X. Li

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The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain, Brendan J. Hilbert, Janelle A. Hayes, Nicholas P. Stone, Rui-Gang Xu, and Brian A. Kelch

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Moxifloxacin Concentration and Proteomic Analysis of Aqueous Humor in Human Uveitis Associated with Oral Moxifloxacin Therapy, David M. Hinkle, Nicole A. Kruh-Garcia, Jonathan N. Kruh, Carolyn Broccardo, Priyanka Doctor, and C. Stephen Foster

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Isolation of a monoclonal antibody from a phage display library binding the rhesus macaque MHC class I allomorph Mamu-A1*001, Nathan Holman, Jason T. Weinfurter, Trevor R. Harsla, Roger W. Wiseman, Aaron J. Belli, Anthony J. Michaels, Keith A. Reimann, Robert I. DeMars, and Matthew R. Reynolds

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Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition, Deli Hong, Terri L. Messier, Coralee E. Tye, Jason Dobson, Andrew J. Fritz, Kenneth R. Sikora, Gillian Browne, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Development of a Reporter System for In Vivo Monitoring of gamma-Secretase Activity in Drosophila, Young Gi Hong, Seyun Roh, Donggi Paik, and Sangyun Jeong

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Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration, Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson, and Scott A. Coonrod

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The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16, Yuqing Hou and George B. Witman

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Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation, Lei Huang, Dongning Pan, Qingbo Chen, Lihua (Julie) Zhu, Jianhong Ou, Martin Wabitsch, and Yong-Xu Wang

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Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky