Founded in 2001, the Department of Neurobiology at the University of Massachusetts Medical School has evolved into a unique and integrated hub of investigators addressing fundamental problems in neurobiology, from single molecules to behavior, primarily using invertebrate model organisms. Combining cell biological, physiological and behavioral analyses with a critical interventionist angle afforded by cutting-edge genetic approaches, the Department aims to understand the complexity of brain development and function. This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurobiology.

Follow


Publications from 2009

PDF

There are many ways to train a fly, Jena L. Pitman, Shamik DasGupta, Michael J. Krashes, Benjamin Leung, Paola N. Perrat, and Scott Waddell

Link

Sleep: what goes up must come down, Jena L. Pitman and Scott Waddell

PDF

Cytoskeletal Regulation and Morphogen Signaling During Synaptic Outgrowth at the Drosophila Larval Neuromuscular Junction : A Dissertation, Preethi Ramachandran

Link

A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN, Preethi Ramachandran, Romina Barria, James A. Ashley, and Vivian Budnik

Link

Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms, Catalina Ruiz-Canada, Daniel J. Kelleher, and Reid Gilmore

PDF

A comparative study of Drosophila and human A-type lamins, Sandra R. Schulze, Beatrice Curio-Penny, Sean D. Speese, George Dialynas, Diane E. Cryderman, Caitrin W. McDonough, Demet Nalbant, Melissa Petersen, Vivian Budnik, Pamela K. Geyer, and Lori L. Wallrath

PDF

The Circadian Clock in Monarch Butterfly: A Tale of Two CRYs: A Dissertation, Quan Yuan

Link

Twin-spot MARCM to reveal the developmental origin and identity of neurons, Hung-Hsiang Yu, Chun-Hong Chen, Lei Shi, Yaling Huang, and Tzumin Lee

PDF

Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis, Hung-Hsiang Yu, Jacob S. Yang, Jian Wang, Yaling Huang, and Tzumin Lee

PDF

Defining behavioral and molecular differences between summer and migratory monarch butterflies, Haisun Zhu, Robert J. Gegear, Amy L. Casselman, Sriramana Kanginakudru, and Steven M. Reppert

Publications from 2008

PDF

The Molecular Mechanisms of Activity-Dependent Wingless (Wg)/Wnt Signaling at a Drosophila Glutamatergic Synapse: a Dissertation, Bulent Ataman

Link

Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling, Bulent Ataman, James A. Ashley, Michael Gorczyca, Preethi Ramachandran, Wernher Fouquet, Stephan J. Sigrist, and Vivian Budnik

PDF

Organization and postembryonic development of glial cells in the adult central brain of Drosophila, Takeshi Awasaki, Sen-Lin Lai, Kei Ito, and Tzumin Lee

Link

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance, Jianwu Bai, Richard Binari, Jian-Quan Ni, Marina Vijayakanthan, Hong-Sheng Li, and Norbert Perrimon

Link

hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction, Andrea Chai, James Withers, Young Ho Koh, Katherine Parry, Hong Bao, Bing Zhang, Vivian Budnik, and Giuseppa Pennetta

Link

Learned odor discrimination in Drosophila without combinatorial odor maps in the antennal lobe, Shamik DasGupta and Scott Waddell

Link

A plastic clock: how circadian rhythms respond to environmental cues in Drosophila, Raphaelle Dubruille and Patrick Emery

Link

Circadian rhythms: timing the sense of smell, Patrick Emery and Michael M. Francis

Link

Cryptochrome mediates light-dependent magnetosensitivity in Drosophila, Robert J. Gegear, Amy L. Casselman, Scott Waddell, and Steven M. Reppert

PDF

Genetic evidence from Indian red jungle fowl corroborates multiple domestication of modern day chicken, Sriramana Kanginakudru, Muralidhar Metta, R. D. Jakati, and J. Nagaraju

Link

Drosophila memory: will Orb(2) predict the future, Michael Jonathan Krashes and Scott Waddell

PDF

Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila, Michael Jonathan Krashes and Scott Waddell

Link

Clonal analysis of Drosophila antennal lobe neurons: diverse neuronal architectures in the lateral neuroblast lineage, Sen-Lin Lai, Takeshi Awasaki, Kei Ito, and Tzumin Lee

Link

Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica, Paula Magnelli, John F. Cipollo, Daniel M. Ratner, Jike Cui, Daniel J. Kelleher, Reid Gilmore, Catherine E. Costello, Phillips W. Robbins, and John Samuelson

PDF

DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function, Carolina Mendoza-Topaz, Francisco Urra, Romina Barria, Valeria Albornoz, Diego Ugalde, Ulrich Thomas, Eckart Gundelfinger, Ricardo Delgado, Manuel Kukuljan, Parthena D. Sanxaridis, Susan Tsunoda, M. Fernanda Ceriani, Vivian Budnik, and Jimena Sierralta

PDF

Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila, Lina Ni, Peiyi Guo, Keith Reddig, Mirna Mitra, and Hong-Sheng Li

Link

Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus, Charlotte von Gall and David R. Weaver

Link

Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function, Rui Wang, Craig S. Walker, Penelope Brockie, Michael M. Francis, Jerry E. Mellem, David M. Madsen, and Andres V. Maricq

PDF

Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam, Jacob S. Yang, Jia-Min Bai, and Tzumin Lee

PDF

The Molecular Mechanisms Underlying the Polarized Distribution of Drosophila Dscam in Neurons: A Dissertation, Shun-Jen Yang

Link

Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling, Shinobu Yasuo, Charlotte von Gall, David R. Weaver, and Horst-Werner Korf

PDF

Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus), Haisun Zhu, Amy L. Casselman, and Steven M. Reppert

PDF

Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation, Haisun Zhu, Ivo Sauman, Quan Yuan, Amy L. Casselman, Myai Emery-Le, Patrick Emery, and Steven M. Reppert

Link

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling, Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley, and Marc R. Freeman

Publications from 2007

Link

Transient, light-induced rhythmicity in mPer-deficient mice, Kiho Bae and David R. Weaver

Link

The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation, Sulagna Banerjee, Prashanth Vishwanath, Jike Cui, Daniel J. Kelleher, Reid Gilmore, Phillips W. Robbins, and John Samuelson

PDF

Molecular and Behavioral Analysis of Drosophila Circadian Photoreception and Circadian Thermoreception: A Dissertation, Ania Busza

PDF

Interactions between circadian neurons control temperature synchronization of Drosophila behavior, Ania Busza, Alejandro D. Murad, and Patrick Emery

Link

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock, Jason P. DeBruyne, David R. Weaver, and Steven M. Reppert

Link

Peripheral circadian oscillators require CLOCK, Jason P. DeBruyne, David R. Weaver, and Steven M. Reppert

Link

Mutagenesis with Drosophila, Patrick Emery

Link

RNA extraction from Drosophila heads, Patrick Emery

Link

RNase protection assay, Patrick Emery

Link

Glia got rhythm, Patrick Emery and Marc R. Freeman

Link

A look inside, Marc R. Freeman

Link

A potential dimerization region of dCAMTA is critical for termination of fly visual response, Ping Gong, Junhai Han, Keith Reddig, and Hong-Sheng Li

PDF

Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin, David Gorczyca, James A. Ashley, Sean Speese, Norberto G. Gherbesi, Ulrich Thomas, Eckart Gundelfinger, L. Sian Gramates, and Vivian Budnik

Link

Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity, Junhai Han, Keith Reddig, and Hong-Sheng Li

Link

Drosophila olfactory memory: single genes to complex neural circuits, Alex Carl Keene and Scott Waddell

Link

Sequential use of mushroom body neuron subsets during drosophila odor memory processing, Michael Jonathan Krashes, Alex Carl Keene, Benjamin M. Leung, J. Douglas Armstrong, and Scott Waddell

PDF

Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation, Sen-Lin Lai

PDF

Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species, Anne Laurencon, Raphaelle Dubruille, Evgeni Efimenko, Guillaume Grenier, Ryan Bissett, Elisabeth Cortier, Vivien Rolland, Peter Swoboda, and Benedicte Durand

Link

Smelling excitement in the antennal lobe, Benjamin M. Leung and Scott Waddell

Link

Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission, Jingjun Li, James A. Ashley, Vivian Budnik, and Manzoor A. Bhat

Link

The scoop on the fly brain: glial engulfment functions in Drosophila, Mary A. Logan and Marc R. Freeman

PDF

Molecular and Neuronal Analysis of Circadian Photoresponses in Drosophila: A Dissertation, Alejandro D. Murad

Link

A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila, Alejandro D. Murad, Myai Emery-Le, and Patrick Emery

PDF

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo, Jamie L. Rickmyre, Shamik DasGupta, Danny Liang-Yee Ooi, Jessica Keel, Ethan Lee, Marc W. Kirschner, Scott Waddell, and Laura A. Lee

Link

Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis, Lei Shi, Suewei Lin, Yelena Grinberg, Yannick Beck, Christina M. Grozinger, Gene E. Robinson, and Tzumin Lee

PDF

Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization, Lei Shi, Hung-Hsiang Yu, Jacob S. Yang, and Tzumin Lee

Link

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization, Peter Soba, Sijun Zhu, Kazuo Emoto, Susan Younger, Shun-Jen Yang, Hung-Hsiang Yu, Tzumin Lee, Lily Yeh Jan, and Yuh-Nung Jan

Link

Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly, Sang-Hun Song, Nuri Ozturk, Tracy R. Denaro, N. Ozlem Arat, Ya-Ting Kao, Haisun Zhu, Dongping Zhong, Steven M. Reppert, and Aziz Sancar

Link

Wnts: up-and-coming at the synapse, Sean D. Speese and Vivian Budnik

PDF

Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks, Quan Yuan, Danielle Metterville, Adriana D. Briscoe, and Steven M. Reppert

Link

Neuronal temporal identity in post-embryonic Drosophila brain, Hung-Hsiang Yu and Tzumin Lee

Publications from 2006

The Role of Cell Adhesion, the Cytoskeleton, and Membrane Trafficking during Synapse Outgrowth: A Dissertation, James A. Ashley

Link

Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP, Bulent Ataman, James A. Ashley, David Gorczyca, Michael Gorczyca, Dennis Mathew, Carolin Wichmann, Stephan J. Sigrist, and Vivian Budnik

Link

Scaffolding proteins at the Drosophila neuromuscular junction, Bulent Ataman, Vivian Budnik, and Ulrich Thomas

Link

Selected methods for the anatomical study of Drosophila embryonic and larval neuromuscular junctions, Vivian Budnik, Michael Gorczyca, and Andreas Prokop

Link

The Fly Neuromuscular Junction: Structure and Function, Vivian Budnik and Catalina Ruiz-Canada

Link

A clock shock: mouse CLOCK is not required for circadian oscillator function, Jason P. DeBruyne, Elizabeth Noton, Christopher M. Lambert, Elizabeth S. Maywood, David R. Weaver, and Steven M. Reppert

Link

The polycomb group protein EZH2 is required for mammalian circadian clock function, Jean-Pierre Etchegaray, Xiaoming Yang, Jason P. DeBruyne, Antoine H.F.M. Peters, David R. Weaver, Thomas Jenuwein, and Steven M. Reppert

PDF

The Drosophila radish gene encodes a protein required for anesthesia-resistant memory, Elisabeth Folkers, Scott Waddell, and William G. Quinn

Link

Sculpting the nervous system: glial control of neuronal development, Marc R. Freeman

Link

Glial cell biology in Drosophila and vertebrates, Marc R. Freeman and Johnna E. Doherty

Link

Plasticity and second messengers during synapse development, Leslie C. Griffith and Vivian Budnik

Link

The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor, Junhai Han, Ping Gong, Keith Reddig, Mirna Mitra, Peiyi Guo, and Hong-Sheng Li

PDF

Genetic Dissection of the Neural Circuitry Underlying Memory Stability in Drosophila: A Dissertation, Alex Carl Keene

Link

Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation, Alex Carl Keene, Michael Jonathan Krashes, Benjamin M. Leung, Jessica A. Bernard, and Scott Waddell

Link

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia, Ya-Huei Kuo, Sean F. Landrette, Susan Ann Heilman, Paola N. Perrat, Lisa Garrett, Pu P. Liu, Michelle M. Le Beau, Scott C. Kogan, and Lucio H. Castilla

Link

Genetic mosaic with dual binary transcriptional systems in Drosophila, Sen-Lin Lai and Tzumin Lee

Link

Peripheral gene expression rhythms in a diurnal rodent, Christopher M. Lambert and David R. Weaver

Link

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

Link

A colorful model of the circadian clock, Steven M. Reppert

Link

Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition, Catalina Ruiz-Canada and Vivian Budnik

Link

Synaptic cytoskeleton at the neuromuscular junction, Catalina Ruiz-Canada and Vivian Budnik

Link

Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary, Brandy L. Rush, Alejandro D. Murad, Patrick Emery, and Jadwiga M. Giebultowicz

PDF

Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain, Jian Wang, Ching-Hsien J. Lee, Suewei Lin, and Tzumin Lee

Link

Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons, Xiaoyan Zheng, Christopher T. Zugates, Zouyan Lu, Lei Shi, Jia-Min Bai, and Tzumin Lee

Link

Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity, Sijun Zhu, Suewei Lin, Chih-Fei Kao, Takeshi Awasaki, Ann-Shyn Chiang, and Tzumin Lee

Publications from 2005

PDF

Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint, James A. Ashley, Mary Packard, Bulent Ataman, and Vivian Budnik

Link

Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

Link

Glial (and neuronal) cells missing, Marc R. Freeman

Link

Glial control of synaptogenesis, Marc R. Freeman

Link

Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling, Antje Jilg, Juliane Moek, David R. Weaver, Horst-Werner Korf, Jorg H. Stehle, and Charlotte von Gall

Link

Mapping the interaction of the STT3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chains, Andrey L. Karamyshev, Daniel J. Kelleher, Reid Gilmore, Arthur E. Johnson, Gunnar von Heijne, and Ingmarie Nilsson

Link

Drosophila memory: dopamine signals punishment, Alex Carl Keene and Scott Waddell

Link

Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus), Christopher M. Lambert, Kazuhiko K. Machida, Laura Smale, Antonio A. Nunez, and David R. Weaver

Link

Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2, Dennis Mathew, Bulent Ataman, Jinyun Chen, Yali Zhang, Susan Cumberledge, and Vivian Budnik

Link

Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics, Philip M. Newton, Keith Tully, Thomas McMahon, Jackie Connolly, Jahan Dadgar, Steven N. Treistman, and Robert O. Messing