Founded in 2001, the Department of Neurobiology at the University of Massachusetts Medical School has evolved into a unique and integrated hub of investigators addressing fundamental problems in neurobiology, from single molecules to behavior, primarily using invertebrate model organisms. Combining cell biological, physiological and behavioral analyses with a critical interventionist angle afforded by cutting-edge genetic approaches, the Department aims to understand the complexity of brain development and function. This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurobiology.

Follow


Publications from 2015

PDF

Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

PDF

Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion, Stanislav Nagy, Yung-Chi Huang, Mark J. Alkema, and David Biron

PDF

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels, Kelly H. Oh, Linu S. Abraham, Chandler Gegg, Christian Silvestri, Yung-Chi Huang, Mark J. Alkema, Jacob Furst, Daniela Raicu, and Hongkyun Kim

Link

Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization, Mary Packard, Vahbiz Jokhi, Baojin Ding, Catalina Ruiz-Canada, James A. Ashley, and Vivian Budnik

PDF

A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior, Jennifer K. Pirri, Diego Rayes, and Mark J. Alkema

PDF

Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

Link

Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages, Dorothy P. Schafer and Beth Stevens

Link

Microglia Function in Central Nervous System Development and Plasticity, Dorothy P. Schafer and Beth Stevens

Link

The molecular ticks of the Drosophila circadian clock, Ozgur Tataroglu and Patrick Emery

PDF

Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks, Ozgur Tataroglu, Xiaohu Zhao, Ania Busza, Jinli Ling, John S. O'Neill, and Patrick Emery

Publications from 2014

PDF

Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo

PDF

A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior, Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason Climer, Christopher M. Lambert, Christopher M. Clark, Mark J. Alkema, and Michael M. Francis

Link

Neuroscience. Astrocytes eyeball axonal mitochondria, Thomas C. Burdett and Marc R. Freeman

PDF

Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila, Ratna Chaturvedi, Keith Reddig, and Hong-Sheng Li

PDF

Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark

PDF

Drosophila learn opposing components of a compound food stimulus, Gaurav Das, Martin Klappenbach, Eleftheria Vrontou, Emmanuel Perisse, Christopher M. Clark, Christopher J. Burke, and Scott Waddell

Link

The hepatic circadian clock modulates xenobiotic metabolism in mice, Jason P. DeBruyne, David R. Weaver, and Robert Dallmann

PDF

PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury, Johnna E. Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-yi Lu, and Marc R. Freeman

Link

Signaling mechanisms regulating Wallerian degeneration, Marc R. Freeman

PDF

A magnetic compass aids monarch butterfly migration, Patrick A. Guerra, Robert J. Gegear, and Steven M. Reppert

PDF

Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction, Kimberly S. Kerr, Yuly F. Fuentes Medel, Cassandra Brewer, Romina Barria, James A. Ashley, Katharine C. Abruzzi, Amy E. Sheehan, Ozge E. Tasdemir, Marc R. Freeman, and Vivian Budnik

Link

The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction, Jennifer R. Kowalski, Hitesh Dube, Denis Touroutine, Kristen M. Rush, Patricia R. Goodwin, Marc Carozza, Zachary Didier, Michael M. Francis, and Peter Juo

PDF

Morning and evening oscillators cooperate to reset circadian behavior in response to light input, Pallavi Lamba, Diana Wentworth, Patrick Emery, and Yong Zhang

PDF

Adult neurogenesis and its promise as a hope for brain repair, Carlos Lois and Wolfgang Kelsch

Link

Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration, Zhuo Luan, Keith Reddig, and Hong-Sheng Li

PDF

DRK/DOS/SOS Converge with Crk/Mbc/dCed-12 to Activate Rac1 during Glial Engulfment of Axonal Debris, Tsai-yi Lu, Johnna E. Doherty, and Marc R. Freeman

Link

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis, Allie Muthukumar, Tobias Stork, and Marc R. Freeman

PDF

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Lukas J. Neukomm, Thomas C. Burdett, Michael A. Gonzalez, Stephan Zuchner, and Marc R. Freeman

Link

Diverse cellular and molecular modes of axon degeneration, Lukas J. Neukomm and Marc R. Freeman

PDF

Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham

PDF

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila, Fillip Port, Hui-Min Chen, Tzumin Lee, and Simon L. Bullock

PDF

Drosophila models of neuronal injury, Timothy M. Rooney and Marc R. Freeman

PDF

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans, Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, and Andrew M. Leifer

PDF

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans, Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, and Andrew M. Leifer

Link

Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes, Tobias Stork, Amy E. Sheehan, Ozge E. Tasdemir-Yilmaz, and Marc R. Freeman

Link

Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation, Lin Sun, James Shay, Melissa McLoed, Kevin Roodhouse, Samuel H. Chung, Christopher M. Clark, Jennifer K. Pirri, Mark J. Alkema, and Christopher V. Gabel

PDF

Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

PDF

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons, Ozge E. Tasdemir-Yilmaz and Marc R. Freeman

Link

Studying circadian rhythms in Drosophila melanogaster, Ozgur Tataroglu and Patrick Emery

Link

Generation of transgenic zebra finches with replication-deficient lentiviruses, Tarciso Velho and Carlos Lois

Link

Trim9 regulates activity-dependent fine-scale topography in Drosophila, Limin Yang, Ruonan Li, Takuya Kaneko, Kendra Takle, Rei K. Morikawa, Laura Essex, Xin Wang, Jie Zhou, Kazuo Emoto, Yang Xiang, and Bing Ye

Link

The genetics of monarch butterfly migration and warning colouration, Shuai Zhan, Wei Zhang, Kristjan Niitepold, Jeremy Hsu, Juan Fernandez Haeger, Myron P. Zalucki, Sonia Altizer, Jacobus C. de Roode, Steven M. Reppert, and Marcus R. Kronforst

Publications from 2013

Link

Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage, Jared R. Auclair, Joshua L. Johnson, Qian Liu, Joseph P. Salisbury, Melissa S. Rotunno, Gregory A. Petsko, Dagmar Ringe, Robert H. Brown Jr., Daryl A. Bosco, and Jeffrey N. Agar

Link

Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells, K. Bienemann, M. S. Staege, S. J. Howe, Miguel Sena-Esteves, H. Hanenberg, and C. M. Kramm

PDF

Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

Link

A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma, David Cachia, Saef Izzy, Thomas W. Smith, and Carolina Ionete

PDF

Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity, Megan M. Corty and Marc R. Freeman

Link

Probing the enigma: unraveling glial cell biology in invertebrates, Jaeda Coutinho-Budd and Marc R. Freeman

PDF

Monoaminergic orchestration of motor programs in a complex C. elegans behavior, Jamie L. Donnelly, Christopher M. Clark, Andrew M. Leifer, Jennifer K. Pirri, Marian Haburcak, Michael M. Francis, Aravinthan D. T. Samuel, and Mark J. Alkema

PDF

A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain, Thomas F. Flood, Michael Gorczyca, Benjamin H. White, Kei Ito, and Motojiro Yoshihara

Link

A single pair of interneurons commands the Drosophila feeding motor program, Thomas F. Flood, Shinya Iguchi, Michael Gorczyca, Benjamin White, Kei Ito, and Motojiro Yoshihara

Link

Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years, Marc R. Freeman and David H. Rowitch

Link

Coldness triggers northward flight in remigrant monarch butterflies, Patrick A. Guerra and Steven M. Reppert

Link

Anatomical basis of sun compass navigation II: The neuronal composition of the central complex of the monarch butterfly, Stanley Heinze, Jeremy Florman, Surainder Asokaraj, Basil el Jundi, and Steven M. Reppert

Link

Identification of distinct tyraminergic and octopaminergic neurons innervating the central complex of the desert locust, Schistocerca gregaria, Uwe Homberg, Jutta Seyfarth, Ulrike Binkle, Maria Monastirioti, and Mark J. Alkema

PDF

Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope, Vahbiz Jokhi, James A. Ashley, John J. Nunnari, Akiko Noma, Naoto ito, Noriko Wakabayashi-Ito, Melissa J. Moore, and Vivian Budnik

PDF

The circadian clock gates the intestinal stem cell regenerative state, Phillip Karpowicz, Yong Zhang, John B. Hogenesch, Patrick Emery, and Norbert Perrimon

Link

Regulation of postsynaptic retrograde signaling by presynaptic exosome release, Ceren Korkut, Yihang Li, Kate Koles, Cassandra Brewer, James A. Ashley, Motojiro Yoshihara, and Vivian Budnik

PDF

Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

Link

Extremes of lineage plasticity in the Drosophila brain, Suewei Lin, Elizabeth C. Marin, Ching-Po Yang, Chih-Fei Kao, Bettye A. Apenteng, Yaling Huang, Michael B. O'Connor, James W. Truman, and Tzumin Lee

Link

The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function, Jennifer M. MacDonald, Johnna E. Doherty, Rachel Hackett, and Marc R. Freeman

PDF

Efficient targeted mutagenesis in the monarch butterfly using zinc finger nucleases, Christine Merlin, Lauren E. Beaver, Orley R. Taylor, Scot A. Wolfe, and Steven M. Reppert

PDF

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo, Stefan Milde, A. Nicole Fox, Marc R. Freeman, and Michael P. Coleman

PDF

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Erik S. Musiek, David R. Weaver, David M. Holtzman, and Garret A. Fitzgerald

Link

Are monarch butterflies true navigators? The jury is still out, Karen S. Oberhauser, Orley R. Taylor, Steven M. Reppert, Hugh Dingle, Kelly R. Nail, Robert M. Pyle, and Carl Stenoien

PDF

dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

PDF

Shocking revelations and saccharin sweetness in the study of Drosophila olfactory memory, Emmanuel Perisse, Christopher J. Burke, Wolf Huetteroth, and Scott Waddell

PDF

Different kenyon cell populations drive learned approach and avoidance in Drosophila, Emmanuel Perisse, Yan Yin, Andrew C. Lin, Suewei Lin, Wolf Huetteroth, and Scott Waddell

Link

Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell

PDF

ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans, Hilary A. Petrash, Alison Philbrook, Marian Haburcak, Belinda Barbagallo, and Michael M. Francis

PDF

A tale of two receptors: Dual roles for ionotropic acetylcholine receptors in regulating motor neuron excitation and inhibition, Alison Philbrook, Belinda Barbagallo, and Michael M. Francis

PDF

The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

PDF

Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require npas4, Shuyin Sim, Salome Antolin, Chia-Wei Lin, Yingxi Lin, and Carlos Lois

Link

GW182 controls Drosophila circadian behavior and PDF-receptor signaling, Yong Zhang and Patrick Emery

Link

A role for Drosophila ATX2 in activation of PER translation and circadian behavior, Yong Zhang, Jinli Ling, Chunyan Yuan, Raphaelle Dubruille, and Patrick Emery

PDF

MonarchBase: the monarch butterfly genome database, Shuai Zhan and Steven M. Reppert

Publications from 2012

Link

Wld(S) Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca(2+) Buffering, Michelle A. Avery, Timothy M. Rooney, Jignesh D. Pandya, Thomas M. Wishart, Thomas H. Gillingwater, James W. Geddes, Patrick G. Sullivan, and Marc R. Freeman

PDF

The Secreted Immunoglobulin Domain Proteins ZIG-5 and ZIG-8 Cooperate with L1CAM/SAX-7 to Maintain Nervous System Integrity, Claire Y. Benard, Cassandra Blanchette, Janine Recio, and Oliver Hobert

Link

Layered reward signalling through octopamine and dopamine in Drosophila, Christopher J. Burke, Wolf Huetteroth, David Owald, Emmanuel Perisse, Michael J. Krashes, Gaurav Das, Daryl Gohl, Marion Silies, Sarah Certel, and Scott Waddell

Link

Circadian rhythms: An electric jolt to the clock, Patrick Emery

PDF

Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

Link

Integration of a retrograde signal during synapse formation by glia-secreted TGF-beta ligand, Yuly F. Fuentes-Medel, James A. Ashley, Romina Barria, Rachel Maloney, Marc R. Freeman, and Vivian Budnik

PDF

Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens, Michael A. Gonzalez, Derek Van Booven, William Hulme, Rick H. Ulloa, Rafael F. Lebrigio Acosta, Jeannette M. Osterloh, Mary Logan, Marc R. Freeman, and Stephan Zuchner

PDF

Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies, Patrick A. Guerra, Christine Merlin, Robert J. Gegear, and Steven M. Reppert

Link

Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain, Stanley Heinze and Steven M. Reppert

Link

Protein Gq modulates termination of phototransduction and prevents retinal degeneration, Wen Hu, Didi Wan, Xiaoming Yu, Jinguo Cao, Peiyi Guo, Hong-Sheng Li, and Junhai Han

Link

Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system, Michael Jensen, Frederic J. Hoerndli, Penelope J. Brockie, Rui Wang, Erica Johnson, Dane Maxfield, Michael M. Francis, David M. Madsen, and Andres V. Maricq

PDF

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation, Hina Kalra, Vivian Budnik, and Suresh Mathivanan

Link

Circadian rhythm of temperature preference and its neural control in Drosophila, Haruna Kaneko, Lauren M. Head, Jinli Ling, Xin Tang, Yilin Liu, Paul E. Hardin, Patrick Emery, and Fumika N. Hamada

Link

Hierarchical deployment of factors regulating temporal fate in a diverse neuronal lineage of the Drosophila central brain, Chih-Fei Kao, Hung-Hsiang Yu, Yisheng He, Jui-Chun Kao, and Tzumin Lee

Link

Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats, Wolfgang Kelsch, Shuyin Sim, and Carlos Lois

PDF

Genetic labeling of neuronal subsets through enhancer trapping in mice, Wolfgang Kelsch, Alberto Stolfi, and Carlos Lois

PDF

Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

PDF

Exosomes go with the Wnt, Kate Koles and Vivian Budnik

Link

Wnt Signaling in Neuromuscular Junction Development, Kate Koles and Vivian Budnik

Link

Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons, Kate Koles, John J. Nunnari, Ceren Korkut, Romina Barria, Cassandra Brewer, Yihang Li, John D. Leszyk, Bing Zhang, and Vivian Budnik

PDF

Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling, Alex C. Koon and Vivian Budnik

PDF

A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut

PDF

Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus, Joseph Lesauter, Christopher M. Lambert, Margaret R. Robotham, Zina Model, Rae Silver, and David R. Weaver

PDF

KAYAK-alpha modulates circadian transcriptional feedback loops in Drosophila pacemaker neurons, Jinli Ling, Raphaelle Dubruille, and Patrick Emery