Founded in 2001, the Department of Neurobiology at the University of Massachusetts Medical School has evolved into a unique and integrated hub of investigators addressing fundamental problems in neurobiology, from single molecules to behavior, primarily using invertebrate model organisms. Combining cell biological, physiological and behavioral analyses with a critical interventionist angle afforded by cutting-edge genetic approaches, the Department aims to understand the complexity of brain development and function. This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurobiology.

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Publications from 2015

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A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation, Hui-Min Chen

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An enhanced gene targeting toolkit for Drosophila: Golic+, Hui-Min Chen, Ya-ling Huang, Barret D. Pfeiffer, Xiaohao Yao, and Tzumin Lee

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Connecting Circadian Genes to Neurodegenerative Pathways in Fruit Flies, Patrick Emery

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Letting Go of JuNK by Disassembly of Adhesive Complexes, Jonathan E. Farley and Marc R. Freeman

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Drosophila Central Nervous System Glia, Marc R. Freeman

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The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion, Shangbang Gao, Lin Xie, Taizo Kawano, Michelle D. Po, Sihui Guan, Mei Zhen, Jennifer K. Pirri, and Mark J. Alkema

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Sensory basis of lepidopteran migration: focus on the monarch butterfly, Patrick A. Guerra and Steven M. Reppert

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Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2, Ananya R. Guntur, Pengyu Gu, Kendra Takle, Jingyi Chen, Yang Xiang, and Chung-Hui Yang

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Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein, Siwei He, Alison Philbrook, Rebecca McWhirter, Christopher V. Gabel, Daniel G. Taub, Maximilian H. Carter, Isabella M. Hanna, Michael M. Francis, and David M. Miller 3rd

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Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila, Wolf Huetteroth, Emmanuel Perisse, Suewei Lin, Martin Klappenbach, Christopher J. Burke, and Scott Waddell

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Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila, Seol Hee Im, Kendra Takle, Juyeon Jo, Daniel T. Babcock, Zhiguo Ma, Yang Xiang, and Michael J. Galko

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Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation, Anagha Khandekar

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Using Drosophila models of Huntington's disease as a translatable tool, Elizabeth A. Lewis and Gaynor A. Smith

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The putative Na(+)/Cl(-)-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis, Zhuo Luan, Caitlin Quigley, and Hong-Sheng Li

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Mesoscopic patterns of neural activity support songbird cortical sequences, Jeffrey E. Markowitz, William A. Liberti III, Grigori Guitchounts, Tarciso Velho, Carlos Lois, and Timothy J. Gardner

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Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

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Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion, Stanislav Nagy, Yung-Chi Huang, Mark J. Alkema, and David Biron

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Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels, Kelly H. Oh, Linu S. Abraham, Chandler Gegg, Christian Silvestri, Yung-Chi Huang, Mark J. Alkema, Jacob Furst, Daniela Raicu, and Hongkyun Kim

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Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization, Mary Packard, Vahbiz Jokhi, Baojin Ding, Catalina Ruiz-Canada, James A. Ashley, and Vivian Budnik

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A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior, Jennifer K. Pirri, Diego Rayes, and Mark J. Alkema

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Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

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Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages, Dorothy P. Schafer and Beth Stevens

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Microglia Function in Central Nervous System Development and Plasticity, Dorothy P. Schafer and Beth Stevens

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The molecular ticks of the Drosophila circadian clock, Ozgur Tataroglu and Patrick Emery

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Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks, Ozgur Tataroglu, Xiaohu Zhao, Ania Busza, Jinli Ling, John S. O'Neill, and Patrick Emery

Publications from 2014

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Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo

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A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior, Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason Climer, Christopher M. Lambert, Christopher M. Clark, Mark J. Alkema, and Michael M. Francis

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Neuroscience. Astrocytes eyeball axonal mitochondria, Thomas C. Burdett and Marc R. Freeman

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Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila, Ratna Chaturvedi, Keith Reddig, and Hong-Sheng Li

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Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark

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Drosophila learn opposing components of a compound food stimulus, Gaurav Das, Martin Klappenbach, Eleftheria Vrontou, Emmanuel Perisse, Christopher M. Clark, Christopher J. Burke, and Scott Waddell

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The hepatic circadian clock modulates xenobiotic metabolism in mice, Jason P. DeBruyne, David R. Weaver, and Robert Dallmann

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PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury, Johnna E. Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-yi Lu, and Marc R. Freeman

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Signaling mechanisms regulating Wallerian degeneration, Marc R. Freeman

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A magnetic compass aids monarch butterfly migration, Patrick A. Guerra, Robert J. Gegear, and Steven M. Reppert

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Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction, Kimberly S. Kerr, Yuly F. Fuentes Medel, Cassandra Brewer, Romina Barria, James A. Ashley, Katharine C. Abruzzi, Amy E. Sheehan, Ozge E. Tasdemir, Marc R. Freeman, and Vivian Budnik

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The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction, Jennifer R. Kowalski, Hitesh Dube, Denis Touroutine, Kristen M. Rush, Patricia R. Goodwin, Marc Carozza, Zachary Didier, Michael M. Francis, and Peter Juo

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Morning and evening oscillators cooperate to reset circadian behavior in response to light input, Pallavi Lamba, Diana Wentworth, Patrick Emery, and Yong Zhang

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Adult neurogenesis and its promise as a hope for brain repair, Carlos Lois and Wolfgang Kelsch

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Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration, Zhuo Luan, Keith Reddig, and Hong-Sheng Li

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DRK/DOS/SOS Converge with Crk/Mbc/dCed-12 to Activate Rac1 during Glial Engulfment of Axonal Debris, Tsai-yi Lu, Johnna E. Doherty, and Marc R. Freeman

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Activity-dependent regulation of astrocyte GAT levels during synaptogenesis, Allie Muthukumar, Tobias Stork, and Marc R. Freeman

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Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Lukas J. Neukomm, Thomas C. Burdett, Michael A. Gonzalez, Stephan Zuchner, and Marc R. Freeman

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Diverse cellular and molecular modes of axon degeneration, Lukas J. Neukomm and Marc R. Freeman

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Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham

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Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila, Fillip Port, Hui-Min Chen, Tzumin Lee, and Simon L. Bullock

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Drosophila models of neuronal injury, Timothy M. Rooney and Marc R. Freeman

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Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans, Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, and Andrew M. Leifer

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Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans, Frederick B. Shipley, Christopher M. Clark, Mark J. Alkema, and Andrew M. Leifer

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Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes, Tobias Stork, Amy E. Sheehan, Ozge E. Tasdemir-Yilmaz, and Marc R. Freeman

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Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation, Lin Sun, James Shay, Melissa McLoed, Kevin Roodhouse, Samuel H. Chung, Christopher M. Clark, Jennifer K. Pirri, Mark J. Alkema, and Christopher V. Gabel

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons, Ozge E. Tasdemir-Yilmaz and Marc R. Freeman

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Studying circadian rhythms in Drosophila melanogaster, Ozgur Tataroglu and Patrick Emery

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Generation of transgenic zebra finches with replication-deficient lentiviruses, Tarciso Velho and Carlos Lois

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Trim9 regulates activity-dependent fine-scale topography in Drosophila, Limin Yang, Ruonan Li, Takuya Kaneko, Kendra Takle, Rei K. Morikawa, Laura Essex, Xin Wang, Jie Zhou, Kazuo Emoto, Yang Xiang, and Bing Ye

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The genetics of monarch butterfly migration and warning colouration, Shuai Zhan, Wei Zhang, Kristjan Niitepold, Jeremy Hsu, Juan Fernandez Haeger, Myron P. Zalucki, Sonia Altizer, Jacobus C. de Roode, Steven M. Reppert, and Marcus R. Kronforst

Publications from 2013

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Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage, Jared R. Auclair, Joshua L. Johnson, Qian Liu, Joseph P. Salisbury, Melissa S. Rotunno, Gregory A. Petsko, Dagmar Ringe, Robert H. Brown Jr., Daryl A. Bosco, and Jeffrey N. Agar

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Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells, K. Bienemann, M. S. Staege, S. J. Howe, Miguel Sena-Esteves, H. Hanenberg, and C. M. Kramm

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Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

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A rare presentation of hypertrophic olivary degeneration secondary to primary central nervous system lymphoma, David Cachia, Saef Izzy, Thomas W. Smith, and Carolina Ionete

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Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity, Megan M. Corty and Marc R. Freeman

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Probing the enigma: unraveling glial cell biology in invertebrates, Jaeda Coutinho-Budd and Marc R. Freeman

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Monoaminergic orchestration of motor programs in a complex C. elegans behavior, Jamie L. Donnelly, Christopher M. Clark, Andrew M. Leifer, Jennifer K. Pirri, Marian Haburcak, Michael M. Francis, Aravinthan D. T. Samuel, and Mark J. Alkema

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A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain, Thomas F. Flood, Michael Gorczyca, Benjamin H. White, Kei Ito, and Motojiro Yoshihara

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A single pair of interneurons commands the Drosophila feeding motor program, Thomas F. Flood, Shinya Iguchi, Michael Gorczyca, Benjamin White, Kei Ito, and Motojiro Yoshihara

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Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years, Marc R. Freeman and David H. Rowitch

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Coldness triggers northward flight in remigrant monarch butterflies, Patrick A. Guerra and Steven M. Reppert

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Anatomical basis of sun compass navigation II: The neuronal composition of the central complex of the monarch butterfly, Stanley Heinze, Jeremy Florman, Surainder Asokaraj, Basil el Jundi, and Steven M. Reppert

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Identification of distinct tyraminergic and octopaminergic neurons innervating the central complex of the desert locust, Schistocerca gregaria, Uwe Homberg, Jutta Seyfarth, Ulrike Binkle, Maria Monastirioti, and Mark J. Alkema

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Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope, Vahbiz Jokhi, James A. Ashley, John J. Nunnari, Akiko Noma, Naoto ito, Noriko Wakabayashi-Ito, Melissa J. Moore, and Vivian Budnik

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The circadian clock gates the intestinal stem cell regenerative state, Phillip Karpowicz, Yong Zhang, John B. Hogenesch, Patrick Emery, and Norbert Perrimon

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Regulation of postsynaptic retrograde signaling by presynaptic exosome release, Ceren Korkut, Yihang Li, Kate Koles, Cassandra Brewer, James A. Ashley, Motojiro Yoshihara, and Vivian Budnik

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Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

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Extremes of lineage plasticity in the Drosophila brain, Suewei Lin, Elizabeth C. Marin, Ching-Po Yang, Chih-Fei Kao, Bettye A. Apenteng, Yaling Huang, Michael B. O'Connor, James W. Truman, and Tzumin Lee

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The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function, Jennifer M. MacDonald, Johnna E. Doherty, Rachel Hackett, and Marc R. Freeman

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Efficient targeted mutagenesis in the monarch butterfly using zinc finger nucleases, Christine Merlin, Lauren E. Beaver, Orley R. Taylor, Scot A. Wolfe, and Steven M. Reppert

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Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo, Stefan Milde, A. Nicole Fox, Marc R. Freeman, and Michael P. Coleman

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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Erik S. Musiek, David R. Weaver, David M. Holtzman, and Garret A. Fitzgerald

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Are monarch butterflies true navigators? The jury is still out, Karen S. Oberhauser, Orley R. Taylor, Steven M. Reppert, Hugh Dingle, Kelly R. Nail, Robert M. Pyle, and Carl Stenoien

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

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Shocking revelations and saccharin sweetness in the study of Drosophila olfactory memory, Emmanuel Perisse, Christopher J. Burke, Wolf Huetteroth, and Scott Waddell

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Different kenyon cell populations drive learned approach and avoidance in Drosophila, Emmanuel Perisse, Yan Yin, Andrew C. Lin, Suewei Lin, Wolf Huetteroth, and Scott Waddell

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Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell

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ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans, Hilary A. Petrash, Alison Philbrook, Marian Haburcak, Belinda Barbagallo, and Michael M. Francis

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A tale of two receptors: Dual roles for ionotropic acetylcholine receptors in regulating motor neuron excitation and inhibition, Alison Philbrook, Belinda Barbagallo, and Michael M. Francis

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The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

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Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require npas4, Shuyin Sim, Salome Antolin, Chia-Wei Lin, Yingxi Lin, and Carlos Lois

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GW182 controls Drosophila circadian behavior and PDF-receptor signaling, Yong Zhang and Patrick Emery

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A role for Drosophila ATX2 in activation of PER translation and circadian behavior, Yong Zhang, Jinli Ling, Chunyan Yuan, Raphaelle Dubruille, and Patrick Emery

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MonarchBase: the monarch butterfly genome database, Shuai Zhan and Steven M. Reppert

Publications from 2012

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Wld(S) Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca(2+) Buffering, Michelle A. Avery, Timothy M. Rooney, Jignesh D. Pandya, Thomas M. Wishart, Thomas H. Gillingwater, James W. Geddes, Patrick G. Sullivan, and Marc R. Freeman

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The Secreted Immunoglobulin Domain Proteins ZIG-5 and ZIG-8 Cooperate with L1CAM/SAX-7 to Maintain Nervous System Integrity, Claire Y. Benard, Cassandra Blanchette, Janine Recio, and Oliver Hobert

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Layered reward signalling through octopamine and dopamine in Drosophila, Christopher J. Burke, Wolf Huetteroth, David Owald, Emmanuel Perisse, Michael J. Krashes, Gaurav Das, Daryl Gohl, Marion Silies, Sarah Certel, and Scott Waddell

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Circadian rhythms: An electric jolt to the clock, Patrick Emery

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Integration of a retrograde signal during synapse formation by glia-secreted TGF-beta ligand, Yuly F. Fuentes-Medel, James A. Ashley, Romina Barria, Rachel Maloney, Marc R. Freeman, and Vivian Budnik

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Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens, Michael A. Gonzalez, Derek Van Booven, William Hulme, Rick H. Ulloa, Rafael F. Lebrigio Acosta, Jeannette M. Osterloh, Mary Logan, Marc R. Freeman, and Stephan Zuchner

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Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies, Patrick A. Guerra, Christine Merlin, Robert J. Gegear, and Steven M. Reppert

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Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain, Stanley Heinze and Steven M. Reppert