Title
Coordination of circadian timing in mammals
UMMS Affiliation
Department of Neurobiology; Reppert Lab; Weaver Lab
Publication Date
2002-08-29
Document Type
Article
Subjects
Active Transport, Cell Nucleus; Animals; Circadian Rhythm; Feedback, Physiological; Gene Expression Regulation; Light; Mammals; Models, Biological; Phosphorylation; Photoreceptor Cells, Vertebrate; Suprachiasmatic Nucleus; Visual Pathways
Disciplines
Neuroscience and Neurobiology
Abstract
Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
DOI of Published Version
10.1038/nature00965
Source
Nature. 2002 Aug 29;418(6901):935-41. Link to article on publisher's site
Journal/Book/Conference Title
Nature
Related Resources
PubMed ID
12198538
Repository Citation
Reppert, Steven M. and Weaver, David R., "Coordination of circadian timing in mammals" (2002). Neurobiology Publications and Presentations. 89.
https://escholarship.umassmed.edu/neurobiology_pp/89