Title
A rhythmic Ror
UMMS Affiliation
Department of Neurobiology; Emery Lab; Reppert Lab
Publication Date
8-19-2004
Document Type
Article
Subjects
ARNTL Transcription Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Humans; Nuclear Receptor Subfamily 1, Group F, Member 1; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Trans-Activators; Transcription Factors
Disciplines
Neuroscience and Neurobiology
Abstract
The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and that their competing activities on the same promoter element drive the rhythm in Bmal1 transcription. This finding defines the second feedback loop in mammals.
DOI of Published Version
10.1016/j.neuron.2004.08.009
Source
Neuron. 2004 Aug 19;43(4):443-6. Link to article on publisher's site
Journal/Book/Conference Title
Neuron
Related Resources
PubMed ID
15312644
Repository Citation
Emery, Patrick and Reppert, Steven M., "A rhythmic Ror" (2004). Neurobiology Publications and Presentations. 76.
https://escholarship.umassmed.edu/neurobiology_pp/76