Title
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
UMMS Affiliation
Department of Neurobiology; Reppert Lab; Weaver Lab
Publication Date
5-2007
Document Type
Article
Subjects
Analysis of Variance; Animals; Basic Helix-Loop-Helix Transcription Factors; Behavior, Animal; CLOCK Proteins; Circadian Rhythm; Gene Expression Regulation; Mice; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Suprachiasmatic Nucleus; Trans-Activators
Disciplines
Neuroscience and Neurobiology
Abstract
Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.
DOI of Published Version
10.1038/nn1884
Source
Nat Neurosci. 2007 May;10(5):543-5. Epub 2007 Apr 8. Link to article on publisher's site
Journal/Book/Conference Title
Nature neuroscience
Related Resources
PubMed ID
17417633
Repository Citation
DeBruyne, Jason P.; Weaver, David R.; and Reppert, Steven M., "CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock" (2007). Neurobiology Publications and Presentations. 47.
https://escholarship.umassmed.edu/neurobiology_pp/47