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Document Type
Journal ArticlePublication Date
2007-10-01Keywords
AnimalsBrain
Cell Differentiation
Drosophila
Drosophila Proteins
Nerve Tissue Proteins
Neurons
Stem Cells
Neuroscience and Neurobiology
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Show full item recordAbstract
Understanding how a vast number of neuron types derive from a limited number of neural progenitors remains a major challenge in developmental neurobiology. In the post-embryonic Drosophila brain, specific neuron types derive from specific progenitors at specific times. This suggests involvement of time-dependent cell fate determinants acting as 'temporal codes' along with lineage cues to specify neuronal cell fates. Interestingly, such temporal codes might be provided not only by several regulators acting in sequence, but also by the differential protein levels of the BTB-zinc finger nuclear protein Chinmo. Identifying temporal codes and determining their origins should allow us to elucidate how neuronal diversification occurs through protracted neurogenesis.Source
Trends Neurosci. 2007 Oct;30(10):520-6. Epub 2007 Sep 6. Link to article on publisher's siteDOI
10.1016/j.tins.2007.07.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38009PubMed ID
17825435Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.tins.2007.07.003