Title

Drosophila Cryptochrome: Variations in Blue

UMMS Affiliation

Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences

Publication Date

2020-02-01

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Enzymes and Coenzymes | Neuroscience and Neurobiology

Abstract

CRYPTOCHROMES (CRYs) are structurally related to ultraviolet (UV)/blue-sensitive DNA repair enzymes called photolyases but lack the ability to repair pyrimidine dimers generated by UV exposure. First identified in plants, CRYs have proven to be involved in light detection and various light-dependent processes in a broad range of organisms. In Drosophila, CRY's best understood role is the cell-autonomous synchronization of circadian clocks. However, CRY also contributes to the amplitude of circadian oscillations in a light-independent manner, controls arousal and UV avoidance, influences visual photoreception, and plays a key role in magnetic field detection. Here, we review our current understanding of the mechanisms underlying CRY's various circadian and noncircadian functions in fruit flies.

Keywords

Drosophila, circadian rhythms, cryptochrome, magnetoreception, photoreception

DOI of Published Version

10.1177/0748730419878290

Source

Foley LE, Emery P. Drosophila Cryptochrome: Variations in Blue. J Biol Rhythms. 2020 Feb;35(1):16-27. doi: 10.1177/0748730419878290. Epub 2019 Oct 10. PMID: 31599203; PMCID: PMC7328257. Link to article on publisher's site

Journal/Book/Conference Title

Journal of biological rhythms

Related Resources

Link to Article in PubMed

PubMed ID

31599203

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