Title
Drosophila Cryptochrome: Variations in Blue
UMMS Affiliation
Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences
Publication Date
2020-02-01
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Enzymes and Coenzymes | Neuroscience and Neurobiology
Abstract
CRYPTOCHROMES (CRYs) are structurally related to ultraviolet (UV)/blue-sensitive DNA repair enzymes called photolyases but lack the ability to repair pyrimidine dimers generated by UV exposure. First identified in plants, CRYs have proven to be involved in light detection and various light-dependent processes in a broad range of organisms. In Drosophila, CRY's best understood role is the cell-autonomous synchronization of circadian clocks. However, CRY also contributes to the amplitude of circadian oscillations in a light-independent manner, controls arousal and UV avoidance, influences visual photoreception, and plays a key role in magnetic field detection. Here, we review our current understanding of the mechanisms underlying CRY's various circadian and noncircadian functions in fruit flies.
Keywords
Drosophila, circadian rhythms, cryptochrome, magnetoreception, photoreception
DOI of Published Version
10.1177/0748730419878290
Source
Foley LE, Emery P. Drosophila Cryptochrome: Variations in Blue. J Biol Rhythms. 2020 Feb;35(1):16-27. doi: 10.1177/0748730419878290. Epub 2019 Oct 10. PMID: 31599203; PMCID: PMC7328257. Link to article on publisher's site
Journal/Book/Conference Title
Journal of biological rhythms
Related Resources
PubMed ID
31599203
Repository Citation
Foley LE, Emery P. (2020). Drosophila Cryptochrome: Variations in Blue. Neurobiology Publications. https://doi.org/10.1177/0748730419878290. Retrieved from https://escholarship.umassmed.edu/neurobiology_pp/262