Title

Structure of an Arc-ane virus-like capsid

UMMS Affiliation

Department of Neurobiology: Budnik Lab

Publication Date

2020-02-01

Document Type

Article

Disciplines

Nervous System | Neuroscience and Neurobiology | Structural Biology | Viruses

Abstract

Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

Keywords

Arc gene, virus-like transfer, neuromuscular junction, structural biology

DOI of Published Version

10.1038/s41593-019-0580-3

Source

Budnik V, Thomson T. Structure of an Arc-ane virus-like capsid. Nat Neurosci. 2020 Feb;23(2):153-154. doi: 10.1038/s41593-019-0580-3. PMID: 31953526. Link to article on publisher's site

Journal/Book/Conference Title

Nature neuroscience

Related Resources

Link to Article in PubMed

PubMed ID

31953526

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