The molecular interplay between axon degeneration and regeneration
Department of Neurobiology; Byrne Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Developmental Neuroscience | Molecular and Cellular Neuroscience
Neurons face a series of morphological and molecular changes following trauma and in the progression of neurodegenerative disease. In neurons capable of mounting a spontaneous regenerative response, including invertebrate neurons and mammalian neurons of the peripheral nervous system (PNS), axons regenerate from the proximal side of the injury and degenerate on the distal side. Studies of Wallerian degeneration slow (Wld(S) /Ola) mice have revealed that a level of coordination between the processes of axon regeneration and degeneration occurs during successful repair. Here, we explore how shared cellular and molecular pathways that regulate both axon regeneration and degeneration coordinate the two distinct outcomes in the proximal and distal axon segments.
Stathmin (SCG10), Wallerian degeneration, axon regeneration, calpain, cytoskeleton, dual leucine zipper kinase, mitochondria, nicotinamide mononucleotide adenylyltransferase (NMNAT)
DOI of Published Version
Dev Neurobiol. 2018 Jul 18. doi: 10.1002/dneu.22627. Link to article on publisher's site
Girouard M, Bueno M, Julian V, Drake S, Byrne AB, Fournier AE. (2018). The molecular interplay between axon degeneration and regeneration. Neurobiology Publications. https://doi.org/10.1002/dneu.22627. Retrieved from https://escholarship.umassmed.edu/neurobiology_pp/233