Title

The molecular interplay between axon degeneration and regeneration

UMMS Affiliation

Department of Neurobiology; Byrne Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Publication Date

2018-07-18

Document Type

Article

Disciplines

Developmental Neuroscience | Molecular and Cellular Neuroscience

Abstract

Neurons face a series of morphological and molecular changes following trauma and in the progression of neurodegenerative disease. In neurons capable of mounting a spontaneous regenerative response, including invertebrate neurons and mammalian neurons of the peripheral nervous system (PNS), axons regenerate from the proximal side of the injury and degenerate on the distal side. Studies of Wallerian degeneration slow (Wld(S) /Ola) mice have revealed that a level of coordination between the processes of axon regeneration and degeneration occurs during successful repair. Here, we explore how shared cellular and molecular pathways that regulate both axon regeneration and degeneration coordinate the two distinct outcomes in the proximal and distal axon segments.

Keywords

Stathmin (SCG10), Wallerian degeneration, axon regeneration, calpain, cytoskeleton, dual leucine zipper kinase, mitochondria, nicotinamide mononucleotide adenylyltransferase (NMNAT)

DOI of Published Version

10.1002/dneu.22627

Source

Dev Neurobiol. 2018 Jul 18. doi: 10.1002/dneu.22627. Link to article on publisher's site

Journal/Book/Conference Title

Developmental neurobiology

Related Resources

Link to Article in PubMed

PubMed ID

30022605

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