Title

A microglia-cytokine axis to modulate synaptic connectivity and function

UMMS Affiliation

Department of Neurobiology; Schafer Lab; Graduate School of Biomedical Sciences, MD/PhD Program

Publication Date

12-1-2017

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

Microglia have recently been recognized as key regulators of synapse development, function, and plasticity. Critical to progressing the field is the identification of molecular underpinnings necessary for microglia to carry out these important functions within neural circuits. Here, we focus a review specifically on roles for microglial cytokine signaling within developing and mature neural circuits. We review exciting new studies demonstrating essential roles for microglial cytokine signaling in axon outgrowth, synaptogenesis and synapse maturation during development, as well as synaptic transmission and plasticity in adulthood. Together, these studies identify microglia and cytokines as critical modulators of neural circuits within the healthy brain, with implications for a broad range of neurological disorders with disruptions in synaptic structure and function.

DOI of Published Version

10.1016/j.conb.2017.10.002

Source

Curr Opin Neurobiol. 2017 Dec;47:138-145. doi: 10.1016/j.conb.2017.10.002. Epub 2017 Nov 6. Link to article on publisher's site

Journal/Book/Conference Title

Current opinion in neurobiology

Comments

Philip Feinberg is a student in the MD/PhD Program in the Graduate School of Biomedical Sciences at UMass Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

29096242

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