The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

UMMS Affiliation

Department of Neurobiology; Alkema Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Publication Date


Document Type



Neuroscience and Neurobiology


Persistent neural activity, a sustained circuit output that outlasts the stimuli, underlies short-term or working memory, as well as various mental representations. Molecular mechanisms that underlie persistent activity are not well understood. Combining in situ whole-cell patch clamping and quantitative locomotion analyses, we show here that the Caenorhabditis elegans neuromuscular system exhibits persistent rhythmic activity, and such an activity contributes to the sustainability of basal locomotion, and the maintenance of acceleration after stimulation. The NALCN family sodium leak channel regulates the resting membrane potential and excitability of invertebrate and vertebrate neurons. Our molecular genetics and electrophysiology analyses show that the C. elegans NALCN, NCA, activates a premotor interneuron network to potentiate persistent motor circuit activity and to sustain C. elegans locomotion. Collectively, these results reveal a mechanism for, and physiological function of, persistent neural activity using a simple animal model, providing potential mechanistic clues for working memory in other systems.


Neural circuits, Sodium channels, Working memory

DOI of Published Version



Nat Commun. 2015 Feb 26;6:6323. doi: 10.1038/ncomms7323.

Journal/Book/Conference Title

Nature Communications


Co-author Jennifer Pirri is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to article in PubMed

PubMed ID