Altered body mass regulation in male mPeriod mutant mice on high-fat diet
Document Type
Journal ArticlePublication Date
2010-07-01Keywords
AnimalsBody Weight
Circadian Rhythm
Dietary Fats
Eating
Female
Male
Mice
Mice, Knockout
Mice, Mutant Strains
Mutation
Period Circadian Proteins
Sex Characteristics
Weight Gain
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
The circadian clock orchestrates most physiological processes in mammals. Disruption of circadian rhythms appears to contribute to the development of obesity and metabolic syndrome. The Period genes mPer1 and mPer2, but not mPer3, are essential for core clock function in mice. To assess the impact of mPer genes on body mass regulation, mPer mutant and control mice were fed a high-fat diet. Here the authors report that male mPer1/2/3 triple-deficient mice gain significantly more body mass than wild-type controls on high-fat diet. Surprisingly, mPer3 single-deficient animals mimicked this phenotype, suggesting a previously unrecognized role for mPer3 in body mass regulation.Source
Chronobiol Int. 2010 Jul;27(6):1317-28. Link to article on publisher's siteDOI
10.3109/07420528.2010.489166Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37890PubMed ID
20653457Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.3109/07420528.2010.489166