Title
Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology; Department of Neurobiology; Yang Xiang Lab; Lois Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Publication Date
2016-01-26
Document Type
Article
Disciplines
Medicinal-Pharmaceutical Chemistry | Nanomedicine | Neuroscience and Neurobiology
Abstract
Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.
Keywords
bioimaging, core/active shell structure, dye-sensitizing, near-infrared, optogenetics, upconversion nanoparticles
DOI of Published Version
10.1021/acsnano.5b06383
Source
ACS Nano. 2016 Jan 26;10(1):1060-6. doi: 10.1021/acsnano.5b06383. Epub 2016 Jan 11. Link to article on publisher's site
Journal/Book/Conference Title
ACS nano
Related Resources
PubMed ID
26736013
Repository Citation
Wu X, Zhang Y, Takle K, Bilsel O, Li ZJ, Lee H, Lois C, Xiang Y, Han G. (2016). Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. Neurobiology Publications and Presentations. https://doi.org/10.1021/acsnano.5b06383. Retrieved from https://escholarship.umassmed.edu/neurobiology_pp/157
Comments
Co-author Kendra Takle is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.