Title
Circadian rhythm of temperature preference and its neural control in Drosophila
UMMS Affiliation
Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Publication Date
2012-10-09
Document Type
Article
Subjects
Drosophila; Body Temperature; Circadian Rhythm
Disciplines
Behavioral Neurobiology
Abstract
A daily body temperature rhythm (BTR) is critical for the maintenance of homeostasis in mammals. Whereas mammals use internal energy to regulate body temperature, ectotherms typically regulate body temperature behaviorally [1]. Some ectotherms maintain homeostasis via a daily temperature preference rhythm (TPR) [2], but the underlying mechanisms are largely unknown. Here, we show that Drosophila exhibit a daily circadian clock-dependent TPR that resembles mammalian BTR. Pacemaker neurons critical for locomotor activity are not necessary for TPR; instead, the dorsal neuron 2 s (DN2s), whose function was previously unknown, is sufficient. This indicates that TPR, like BTR, is controlled independently from locomotor activity. Therefore, the mechanisms controlling temperature fluctuations in fly TPR and mammalian BTR may share parallel features. Taken together, our results reveal the existence of a novel DN2-based circadian neural circuit that specifically regulates TPR; thus, understanding the mechanisms of TPR will shed new light on the function and neural control of circadian rhythms.
DOI of Published Version
10.1016/j.cub.2012.08.006
Source
Curr Biol. 2012 Oct 9;22(19):1851-7. doi: 10.1016/j.cub.2012.08.006. Link to article on publisher's site
Journal/Book/Conference Title
Current biology : CB
Related Resources
PubMed ID
22981774
Repository Citation
Kaneko H, Head LM, Ling J, Tang X, Liu Y, Hardin PE, Emery P, Hamada FN. (2012). Circadian rhythm of temperature preference and its neural control in Drosophila. Neurobiology Publications. https://doi.org/10.1016/j.cub.2012.08.006. Retrieved from https://escholarship.umassmed.edu/neurobiology_pp/139
Comments
Co-author Jinli Ling is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.