Glia instruct developmental neuronal remodeling through TGF-beta signaling
Department of Neurobiology; Tzumin Lee Lab
Animals; Animals, Genetically Modified; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; MicroRNAs; *Models, Neurological; Mushroom Bodies; Mutation; Neurogenesis; Neuroglia; RNA, Double-Stranded; Signal Transduction; Transforming Growth Factor beta
Neuroscience and Neurobiology
We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
DOI of Published Version
Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. Link to article on publisher's site
Awasaki, Takeshi; Huang, Ya-ling; O'Connor, Michael B.; and Lee, Tzumin, "Glia instruct developmental neuronal remodeling through TGF-beta signaling" (2011). Neurobiology Publications and Presentations. 131.