Glia instruct developmental neuronal remodeling through TGF-beta signaling
Document Type
Journal ArticlePublication Date
2011-06-19Keywords
AnimalsAnimals, Genetically Modified
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
MicroRNAs
*Models, Neurological
Mushroom Bodies
Mutation
Neurogenesis
Neuroglia
RNA, Double-Stranded
Signal Transduction
Transforming Growth Factor beta
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.Source
Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. Link to article on publisher's siteDOI
10.1038/nn.2833Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37862PubMed ID
21685919Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nn.2833