Title

Similarity of Visual Selectivity among Clonally Related Neurons in Visual Cortex

UMMS Affiliation

Department of Neurobiology; Lois Lab

Publication Date

2012-07-12

Document Type

Article

Subjects

Visual Cortex; Neurons

Disciplines

Neuroscience and Neurobiology

Abstract

Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.

DOI of Published Version

10.1016/j.neuron.2012.05.023

Source

Neuron. 2012 Jul 12;75(1):65-72. Link to article on publisher's site

Journal/Book/Conference Title

Neuron

Related Resources

Link to Article in PubMed

PubMed ID

22794261

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