Title
Similarity of Visual Selectivity among Clonally Related Neurons in Visual Cortex
UMMS Affiliation
Department of Neurobiology; Lois Lab
Publication Date
2012-07-12
Document Type
Article
Subjects
Visual Cortex; Neurons
Disciplines
Neuroscience and Neurobiology
Abstract
Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.
DOI of Published Version
10.1016/j.neuron.2012.05.023
Source
Neuron. 2012 Jul 12;75(1):65-72. Link to article on publisher's site
Journal/Book/Conference Title
Neuron
Related Resources
PubMed ID
22794261
Repository Citation
Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K. (2012). Similarity of Visual Selectivity among Clonally Related Neurons in Visual Cortex. Neurobiology Publications and Presentations. https://doi.org/10.1016/j.neuron.2012.05.023. Retrieved from https://escholarship.umassmed.edu/neurobiology_pp/119