Title
Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics
UMMS Affiliation
Department of Neurobiology; Yoshihara Lab
Publication Date
2012-03-15
Document Type
Article
Subjects
Genetics, Behavioral; Molecular Biology; Nerve Net; Neurons
Disciplines
Neuroscience and Neurobiology
Abstract
This review summarizes technical development of the functional manipulation of specific neural circuits through genetic techniques in Drosophila. Long after pioneers' efforts for the genetic dissection of behavior using this organism as a model, analyses with acute activation of specific neural circuits have finally become feasible using transgenic Drosophila that expresses light-, heat-, or cold-activatable cation channels by xxx/upstream activation sequence (Gal4/UAS)-based induction system. This methodology opened a new avenue to dissect functions of neural circuits to make dreams of the pioneers into reality.
DOI of Published Version
10.3109/01677063.2012.663429
Source
J Neurogenet. 2012 Mar;26(1):43-52. Epub 2012 Mar 15. Link to article on publisher's site
Journal/Book/Conference Title
Journal of neurogenetics
Related Resources
PubMed ID
22420407
Repository Citation
Yoshihara, Moto and Ito, Kei, "Acute genetic manipulation of neuronal activity for the functional dissection of neural circuits-a dream come true for the pioneers of behavioral genetics" (2012). Neurobiology Publications and Presentations. 117.
https://escholarship.umassmed.edu/neurobiology_pp/117