This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

Follow


Publications from 2020

Link

Call to Action: SARS-CoV-2 and Cerebrovascular Disorders (CASCADE), Shahram Abootalebi, M. Reza Azarpazhooh, Mario Di Napoli, and Brian Silver

Link

Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke, Zimbul Albo, Jose Marino, Muhammad Nagy, Dilip K. Jayaraman, Muhammad U. Azeem, Ajit S. Puri, and Nils Henninger

PDF

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD, Nadja S. Andrade, Abbas Abdallah, Christian Mueller, and Zane Zeier

Link

COVID-19 Pandemic and Burden of Non-Communicable Diseases: An Ecological Study on Data of 185 Countries, M. Reza Azarpazhooh, Brian Silver, and Mario Di Napoli

PDF

Guidelines for TMS/tES Clinical Services and Research through the COVID-19 Pandemic, Marom Bikson, Gottfried Schlaug, and Hamed Ekhtiari

PDF

Upregulating beta-hexosaminidase activity in rodents prevents alpha-synuclein lipid associations and protects dopaminergic neurons from alpha-synuclein-mediated neurotoxicity, Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, and Penelope J. Hallett

Link

Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation, Jan T. Czerminski and Jeanne B. Lawrence

PDF

Bilateral Basal Ganglia Hemorrhage in a Patient with Confirmed COVID-19, Rrita Daci, Megan Kennelly, Annie Ferris, Muhammad U. Azeem, Mark D. Johnson, Farid Hamzei-Sichani, Adalia H. Jun-O'Connell, and Sabareesh K. Natarajan

PDF

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency, Jonathan Frew, Fen-Biao Gao, and Haakon B. Nygaard

PDF

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease, Michael T. Heneka, Douglas T. Golenbock, Eicke Latz, Dave Morgan, and Robert H. Brown Jr.

PDF

Longitudinal biomarkers in amyotrophic lateral sclerosis, Fen Huang, Yuda Zhu, Jennifer Hsiao-Nakamoto, Xinyan Tang, Jason C. Dugas, Miriam Moscovitch-Lopatin, Jonathan D. Glass, Robert H. Brown Jr., Shafeeq S. Ladha, David Lacomis, Jeffrey M. Harris, Kimberly Scearce-Levie, Carole Ho, Robert Bowser, and James D. Berry

PDF

CRISPR deletion of the C9ORF72 promoter in ALS/FTD patient motor neurons abolishes production of dipeptide repeat proteins and rescues neurodegeneration, Gopinath Krishnan, Yu Zhang, Yuanzheng Gu, Mark W. Kankel, Fen-Biao Gao, and Sandra Almeida

Link

Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System, Alexandra Kvernland and Nils Henninger

Link

Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy, Angela Lek, Alec DeSimone, Oliver D. King, and Louis M. Kunkel

PDF

Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD, Shuangxi Li, Zhihao Wu, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Gopinath Krishnan, Fen-Biao Gao, Hannes Vogel, and Bingwei Lu

PDF

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder, Hua Liu, Andrew W. Zimmerman, Kanwaljit Singh, Susan Connors, Eileen Diggins, Katherine K. Stephenson, Albena T. Dinkova-Kostova, and Jed W. Fahey

Link

COVID-19 in teriflunomide-treated patients with multiple sclerosis, Amir Hadi Maghzi, Maria K. Houtchens, Paolo Preziosa, Carolina Ionete, Biljana D. Beretich, James M. Stankiewicz, Shahamat Tauhid, Ann Cabot, Idanis M. Berrios Morales, Tamara H. W. Schwartz, Jacob A. Sloane, Mark S. Freedman, Massimo Filippi, Howard L. Weiner, and Rohit Bakshi

Link

Gaucher disease and SARS-CoV-2 infection: Emerging management challenges, Pramod Mistry, Edward I. Ginns, and Ellen Sidransky

Link

Neurocritical Care Resource Utilization in Pandemics: A Statement by the Neurocritical Care Society, Asma M. Moheet and Wiley R. Hall

Link

A paradox of social distancing for SARS-CoV-2: loneliness and heightened immunological risk, Liron Rozenkrantz, Michael H. Bernstein, and Christopher C. Hemond

Link

Nuclear hubs built on RNAs and clustered organization of the genome, Kelly P. Smith, Lisa L. Hall, and Jeanne B. Lawrence

Link

Sudden olfactory loss as an early marker of COVID-19: a nationwide Italian survey, Lucrezia Spadera, Alfonso Scarpa, and Raffaella Pizzolato

Link

Volume and Infusion Rate Dynamics of Intraparenchymal Central Nervous System Infusion in a Large Animal Model, Toloo Taghian, Erin Horn, Mohammed S. Shazeeb, Lindsey J. Bierfeldt, Susan M. Tuominen, Jennifer Koehler, Deborah Fernau, Stephanie Bertrand, Stephen Frey, Oguz Cataltepe, Matthew J. Gounis, Aly Abayazeed, Terence R. Flotte, Miguel Sena-Esteves, and Heather Gray-Edwards

PDF

Lower Ca2+ enhances the K+-induced force depression in normal and HyperKPP mouse muscles, Francine Uwera, Tarek Ammar, Callum McRae, Lawrence J. Hayward, and Jean-Marc Renaud

Publications from 2019

PDF

Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells, Sandra Almeida, Gopinath Krishnan, Mia Rushe, Yuanzheng Gu, Mark W. Kankel, and Fen-Biao Gao

Link

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

Link

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS, Desiree Baron, Tyler Matheny, Yen-Chen Lin, John D. Leszyk, Kevin P. Kenna, Katherine V. Gall, David P. Santos, Maeve Tischbein, Salome Funes, Lawrence J. Hayward, Evangelos Kiskinis, John E. Landers, Roy Parker, Scott A. Shaffer, and Daryl Bosco

Link

Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

PDF

A Novel Tool to Improve Shared Decision Making and Adherence in Multiple Sclerosis: Development and Preliminary Testing, Nananda Col, Enrique Alvarez, Vicky Springmann, Carolina Ionete, Idanis Berrios Morales, Andrew Solomon, Christen Kutz, Carolyn Griffin, Brenda Tierman, Terrie Livingston, Michelle Patel, Danny van Leeuwen, Long Ngo, and Lori Pbert

PDF

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis, Johnathan Cooper-Knock, John E. Landers, and Pamela J. Shaw

PDF

Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy, Alec M. DeSimone; John D. Leszyk; Kathryn Wagner; and Charles P. Emerson, Jr.

PDF

Accuracy and Usability of a Novel Algorithm for Detection of Irregular Pulse Using a Smartwatch Among Older Adults: Observational Study, Eric Y. Ding, Dong Han, Cody Whitcomb, Syed Khairul Bashar, Oluwaseun Adaramola, Apurv Soni, Jane Saczynski, Timothy P. Fitzgibbons, Majaz Moonis, Steven A. Lubitz, Darleen M. Lessard, Mellanie True Hills, Bruce A. Barton, Ki Chon, and David D. McManus

PDF

Correction of pseudoexon splicing caused by a novel intronic dysferlin mutation, Janice A. Dominov, Ozgun Uyan, Diane McKenna-Yasek, Babi Ramesh Reddy Nallamilli, Virginie Kergourlay, Marc Bartoli, Nicolas Levy, Judith Hudson, Teresinha Evangelista, Hanns Lochmuller, Martin Krahn, Laura Rufibach, Madhuri Hegde, and Robert H. Brown Jr.

PDF

Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1, Vera Fridman, Saranya Suriyanarayanan, Peter Novak, William David, Eric A. Macklin, Diane McKenna-Yasek, Kailey Walsh, Razina Aziz-Bose, Anne Louise Oaklander, Robert H. Brown Jr., Thorsten Hornemann, and Florian Eichler

PDF

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis, Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown Jr., Antonia Ratti, John E. Landers, and Claudia Fallini

Link

A pilot study evaluating a simple cardiac dysfunction score to predict complications and survival among critically-ill patients with traumatic brain injury, Patric W. Gibbons, Robert J. Goldberg, and Susanne Muehlschlegel

PDF

Selection of an Efficient AAV Vector for Robust CNS Transgene Expression, Killian S. Hanlon, Miguel Sena-Esteves, Eloise Hudry, and Casey A. Maguire

PDF

The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis, Christopher C. Hemond, Bonnie I. Glanz, Rohit Bakshi, Tanuja Chitnis, and Brian C. Healy

Link

Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

PDF

Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation, Janel O. Johnson, Ruth Chia, Robert H. Brown Jr., and John E. Landers

PDF

Intralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model, Allison M. Keeler, Marina Zieger, Carson Semple, Logan Pucci, Alessandra Veinbachs, Robert H. Brown Jr., Christian Mueller, and Mai K. Elmallah

Link

Impact of age on cerebral aneurysm occlusion after flow diversion, Anna Luisa Kuhn, Peter Kan, Nils Henninger, Visish Srinivasan, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Matthew J. Gounis, and Ajit S. Puri

PDF

Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis, Yvonne L. Latour, Robin Yoon, Sarah E. Thomas, Christina Grant, Cuiling Li, Miguel Sena-Esteves, Maria L. Allende, Richard L. Proia, and Cynthia J. Tifft

PDF

Potential use of leukocytosis and anion gap elevation in differentiating psychogenic nonepileptic seizures from epileptic seizures, Yi Li, Liesl Matzka, Julie Flahive, and Daniel Weber

PDF

Reduction in apathy following epilepsy surgery, Linda Mah, Joan M. Swearer, Catherine A. Phillips, and Sheldon Benjamin

PDF

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

PDF

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1, Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, and Xandra O. Breakefield

Link

Sensory dysphagia: A case series and proposed classification of an under recognized swallowing disorder, Laura F. Santoso, Daniel Y. Kim, and David Paydarfar

Link

12 versus 24 h bed rest after acute ischemic stroke thrombolysis: a preliminary experience, Brian Silver, Majaz Moonis, Nils Henninger, Richard P. Goddeau Jr, Adalia H. Jun-O'Connell, Wiley R. Hall, Susanne Muehlschlegel, Raphael A. Carandang, and Marcey Osgood

Link

A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna, Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King, Deborah Fernau, Ana Rita Batista, Terence R. Flotte, Diane McKenna-Yasek, Phillip W. L. Tai L, Neil Aronin, Matthew J. Gounis, Miguel Sena-Esteves, and Heather L. Gray-Edwards

PDF

The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing, Maeve Tischbein, Desiree M. Baron, Yen-Chen Lin, Katherine V. Gall, John E. Landers, Claudia Fallini, and Daryl A. Bosco

PDF

gMS-Classifier1 does not predict disability progression in multiple sclerosis, Johannis A. van Rossum, Joep Killestein, Luisa M. Villar, Peter N. Riskind, Mark S. Freedman, and Charlotte Teunissen

PDF

Gap Analysis Regarding Prognostication in Neurocritical Care: A Joint Statement from the German Neurocritical Care Society and the Neurocritical Care Society, Katja E. Wartenberg, David Y. Hwang, Karl Georg Haeusler, Susanne Muehlschlegel, Oliver W. Sakowitz, Dominik Madzar, Hajo M. Hamer, Alejandro A. Rabinstein, David M. Greer, J. Claude Hemphill 3rd, Juergen Meixensberger, and Panayiotis N. Varelas

Link

Nucleic Acid Therapeutics for Neurological Diseases, Jonathan K. Watts, Robert H. Brown Jr., and Anastasia Khvorova

Publications from 2018

PDF

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation, Maria L. Allende, Emily K. Cook, Bridget C. Larman, Adrienne Nugent, Jacqueline M. Brady, Diane Golebiowski, Miguel Sena-Esteves, Cynthia J. Tifft, and Richard L. Proia

Link

Safe and effective superoxide dismutase 1 silencing using artificial microRNA in macaques, Florie Borel, Gwladys Gernoux, Huaming Sun, Rachel Stock, Meghan Blackwood, Robert H. Brown Jr., and Christian Mueller

PDF

Time management in a co-housed social rodent species (Arvicanthis niloticus), Alexandra Castillo-Ruiz, Premananda Indic, and William J. Schwartz

PDF

Evolution of extrema features reveals optimal stimuli for biological state transitions, Joshua TsuKang Chang and David Paydarfar

PDF

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2alpha phosphorylation, Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland, and Shuying Sun

PDF

Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro, Jen-Chieh Chiang, Jun Jiang, Peter E. Newburger, and Jeanne B. Lawrence

Link

Evaluation of a Novel Preference Assessment Tool for Patients with Multiple Sclerosis, Nananda F. Col, Andrew J. Solomon, Vicky Springmann, Carolina Ionete, Enrique Alvarez, Brenda Tierman, Christen Kutz, Idanis M. Berrios Morales, Carolyn Griffin, Long H. Ngo, David E. Jones, Glenn Phillips, Ashli Hopson, and Lori Pbert

PDF

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function, Martina de Majo, Kevin P. Kenna, Robert H. Brown Jr., John E. Landers, and Christopher E. Shaw

PDF

Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin, Marie C. Didiot, Chantal M. Ferguson, Socheata Ly, Andrew H. Coles, Abigail O. Smith, Alicia A. Bicknell, Lauren M. Hall, Ellen Sapp, Dimas Echeverria, Athma A. Pai, Marian DiFiglia, Melissa J. Moore, Lawrence J. Hayward, Neil Aronin, and Anastasia Khvorova

Link

"Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients, Nils Henninger, Rebecca A. Compton, Muhammad W. Khan, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

PDF

Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women's Health Initiative, Lisette T. Jacobson, Erinn M. Hade, Tracie C. Collins, Karen L. Margolis, Molly E. Waring, Linda V. Van Horn, Brian Silver, Maryam Sattari, Chloe E. Bird, Kim Kimminau, Karen Wambach, and Marcia L. Stefanick

Link

Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease, Allison M. Keeler, Marina Zieger, Sophia H. Todeasa, Angela L. McCall, Jennifer C. Gifford, Samantha Birsak, Sourav Roy Choudhury, Barry J. Byrne, Miguel Sena-Esteves, and Mai K. Elmallah

PDF

Recent Trends in Oral Anticoagulant Use and Post-Discharge Complications Among Atrial Fibrillation Patients with Acute Myocardial Infarction, Amartya Kundu, Kevin O. Day, Darleen M. Lessard, Joel M. Gore, Hong Yu, Mohammed W. Akhter, Daniel Z. Fisher, Robert M. Hayward Jr, Nils Henninger, Alok Kapoor, Jorge L. Yarzebski, Robert J. Goldberg, and David D. McManus

PDF

A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells, Andreas Kurtz, Stefanie Seltmann, and Kelly P. Smith

PDF

Ephrinb3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpineinduced model of epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, and Li Feng

Link

Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke, Yunis M. Mayasi, Johanna Helenius, David D. McManus, Richard P. Goddeau Jr, Adalia H. Jun-O'Connell, Majaz Moonis, and Nils Henninger

PDF

Should We Use the IMPACT-Model for the Outcome Prognostication of TBI Patients? A Qualitative Study Assessing Physicians' Perceptions, Jesse Moskowitz, Thomas Quinn, Muhammad W. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

Link

Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs, Maire F. Osborn, Andrew H. Coles, Diane Golebiowski, Dimas Echeverria, Michael P. Moazami, Jonathan K. Watts, Miguel Sena-Esteves, and Anastasia Khvorova

PDF

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1, Maria Perez Carrion, John E. Landers, Stefano Goldwurm, and Giovanni Piccoli

PDF

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis, Owen M. Peters, Elizabeth A. Lewis, Jeannette M. Osterloh, Alexandra Weiss, Johnny Salameh, Jake P. Metterville, Robert H. Brown Jr., and Marc R. Freeman

PDF

Herpes ICP8 protein stimulates homologous recombination in human cells, Melvys Valledor, Richard S. Myers, and Paul C. Schiller

PDF

Herpes ICP8 protein stimulates homologous recombination in human cells, Melvys Valledor, Richard S. Myers, and Paul C. Schiller

PDF

Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks, Shuo Wang, Erik D. Herzog, Istvan Z. Kiss, William J. Schwartz, Guy Bloch, Michael Sebek, Daniel Granados-Fuentes, Liang Wang, and Jr-Shin Li

Publications from 2017

Link

Atrial fibrillation, cognition and dementia: A review, Summer Aldrugh, Mayank Sardana, Nils Henninger, Jane S. Saczynski, and David D. McManus

PDF

Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy

Link

The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better, Katarina Cheng, Ribal Bassil, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

PDF

XIST RNA: a window into the broader role of RNA in nuclear chromosome architecture, Kevin Creamer and Jeanne B. Lawrence

PDF

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

Link

Direct Intracranial Injection of AAVrh8 Encoding Monkey beta-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain, Diane Golebiowski, Imramsjah M. J. van der Bom, Churl-Su Kwon, Andrew D. Miller, Keiko Petrosky, Allison M. Bradbury, Stacy A. Maitland, Anna L. Kuhn, Nina Bishop, Elizabeth Curran, Nilsa Silva, Dwijit Guhasarkar, Susan V. Westmoreland, Douglas R. Martin, Matthew J. Gounis, Wael F. Asaad, and Miguel Sena-Esteves

PDF

Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy, Heather L. Gray-Edwards, Xuntian Jiang, Ashley N. Randle, Amanda R. Taylor, Taylor L. Voss, Aime K. Johnson, Victoria J. McCurdy, Miguel Sena-Esteves, Daniel S. Ory, and Douglas R. Martin

PDF

Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves

PDF

Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies, Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew H. Fischer, Peter L. Jones, and Jeanne B. Lawrence

PDF

Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger

Link

The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis, Adalia H. Jun-O'Connell, Ankur A. Butala, Idanis Berrios Morales, Nils Henninger, Kristina M. Deligiannidis, Nancy Byatt, and Carolina Ionete

Link

Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort, Muhib A. Khan, Grayson L. Baird, David Miller, Anand Patel, Shawn Tsekhan, Shadi Yaghi, Ajit S. Puri, Mahesh Jayaraman, Nils Henninger, and Brian Silver

PDF

Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, and Nils Henninger

PDF

Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis, Kannikar Kongbunkiat, Duncan Wilson, Narongrit Kasemsap, Somsak Tiamkao, Fatima Jichi, Vanessa Palumbo, Michael D. Hill, Alastair M. Buchan, Simon Jung, Heinrich P. Mattle, Nils Henninger, and David J. Werring

PDF

The lysosomal protein cathepsin L is a progranulin protease, Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, and Leonard Petrucelli

PDF

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

Link

Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease, Edith L. Pfister, Natalie Dinardo, Erica Mondo, Florie Borel, Faith Conroy, Gwladys Gernoux, Lori A. Kennington, Richard P. Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, and Neil Aronin

PDF

A general neurologist's perspective on the urgent need to apply resilience thinking to the prevention and treatment of Alzheimer's disease, Grazyna Pomorska and Judith K. Ockene

PDF

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis, Project MinE Consortium, Wouter Van Rheenen, Kevin P. Kenna, John E. Landers, and Jan H. Veldink

Link

What Families Need and Physicians Deliver: Contrasting Communication Preferences Between Surrogate Decision-Makers and Physicians During Outcome Prognostication in Critically Ill TBI Patients, Thomas Quinn, Jesse Moskowitz, Muhammad A. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

PDF

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation, Reddy Ranjith Kumar Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, and Daryl Bosco

PDF

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype, Pamela J. Shaw, Kevin P. Kenna, and John E. Landers

PDF

RAHI-SATHI Indo-U.S. Collaboration: The Evolution of a Trainee-Led Twinning Model in Global Health Into a Multidisciplinary Collaborative Program, Apurv Soni, Nisha Fahey, Abraham Jaffe, Tiffany A. Moore Simas, Nancy Byatt, Michael Chin, David D. McManus, Michaela Tracey, Jasmine A. Khubchandani, Haley Newman, Allison Earon, Hannah Rosenfield, Anna Handorf, Brittany Novak, John Bostrom, Anindita Deb, Milagros C. Rosal, Patricia A. McQuilkin, Heena Santry, Melissa A. Fischer, and Jeroan J. Allison