This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 1996

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway, Carol F. Lippa, Ann M. Saunders, Thomas W. Smith, Joan M. Swearer, David A. Drachman, Bernardino Ghetti, Linda Nee, D. Pulaski-Salo, Dennis Dickson, Yves Robitaille, C. Bergeron, Barbara Crain, Merrill D. Benson, Martin R. Farlow, Bradley T. Hyman, Peter H. St. George-Hyslop, Allen D. Roses, and Daniel A. Pollen

Foreign Accent Syndrome Following a Closed Head Injury: Perfusion Deficit on Single Photon Emission Tomography with Normal Magnetic Resonance Imaging, Majaz Moonis, Joan M. Swearer, S. E. Blumstein, K. Kurowski, Robert Licho, P. Kramer, Ann L. Mitchell, Diane L. Osgood, and David A. Drachman

Medical therapy for ischemic stroke, Brian Silver, Johannes Weber, and Marc Fisher

Predicting Aberrant Behavior in Alzheimer's Disease, Joan M. Swearer, Nancy E. Hoople, Kevin J. Kane, and David A. Drachman

Rate of progression in familial Alzheimer's disease, Joan M. Swearer, Brian F. O'Donnell, Susan M. Ingram, and David A. Drachman

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The role of spreading depression in focal ischemia evaluated by diffusion mapping, Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, Christopher H. Sotak, and Marc Fisher

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Hematologic disorders associated with ischemic stroke, Turgut Tatlisumak and Marc Fisher

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Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging, Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, and Marc Fisher

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Middle fossa cyst presenting as a delayed complication of temporal lobectomy: case report, John P. Weaver, Catherine Phillips, Sandra L. Horowitz, and Sheldon Benjamin

Publications from 1995

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Acute stroke treatment trials in the United States. Rethinking strategies for success, Robert J. Adams, Marc Fisher, Anthony J. Furlan, and Gregory del Zoppo

Diagnosis and evaluation of dementia, Jody Corey-Bloom, Leon J. Thal, Douglas R. Galasko, Marshall F. Folstein, David A. Drachman, Murray A. Raskind, and Douglas J. Lanska

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Diffusion and perfusion imaging for acute stroke, Marc Fisher

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Potentially effective therapies for acute ischemic stroke, Marc Fisher

Stroke Therapy, Marc Fisher

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Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats, Marc Fisher, Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein

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ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study, Marc Fisher, Michael S. Pessin, and Anthony J. Furian

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Cortical blindness after correction of symptomatic hyponatremia: dynamic cerebral dysfunction visualized using serial SPECT scanning, Catherine Hagerty, Robert Licho, and Lawrence D. Recht

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Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain, Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, Christopher H. Sotak, and Marc Fisher

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Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization, Randall R. Long, David J. Elliott, Francoise Stutz, Michael Rosbash, and Robert H. Singer

Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease, James F. Paskavitz, Carol F. Lippa, James E. Hamos, D. Pulaski-Salo, and David A. Drachman

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Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model, W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, Christopher H. Sotak, and Marc Fisher

Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know, Sudha Seshadri, David A. Drachman, and Carol F. Lippa

Publications from 1994

Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume, Ronald A. Cohen, Yasuhiro Hasegawa, and Marc Fisher

Dizziness, David A. Drachman

If we live long enough, will we all be demented, David A. Drachman

Neurological Evaluation in the Elderly Patient, David A. Drachman, Randall R. Long, and Joan M. Swearer

Clinical Atlas of Cerebrovascular Disorders, Marc Fisher

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Prophylactic neuroprotection for cerebral ischemia, Marc Fisher, Saran Jonas, and Ralph L. Sacco

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The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke, Yasuhiro Hasegawa, Marc Fisher, Bruce M. Baron, and Geoffrey Metcalf

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MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia, Yasuhiro Hasegawa, Marc Fisher, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak

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Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats, Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, Bernard J. Dardzinski, and Marc Fisher

Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain, Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, Marc Fisher, and Christopher H. Sotak

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Retrograde axonal transport and lesion-induced upregulation of the TrkA high-affinity NGF receptor, Rebekah Loy, Mahesh B. Lachyankar, Peter J. Condon, Dorota K. Poluha, and Alonzo H. Ross

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Dynamics of synapsin I gene expression during the establishment and restoration of functional synapses in the rat hippocampus, Richard H. Melloni, Paul J. Apostolides, James E. Hamos, and Louis J. DeGennaro

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Temporal onset of synapsin I gene expression coincides with neuronal differentiation during the development of the nervous system, Richard H. Melloni and Louis J. DeGennaro

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium, Takehide Tsuda, Robert F. Lopez-Alberola, Evgeny A. Rogaeva, Morris Freedman, Evgeny I. Rogaev, David A. Drachman, Daniel A. Pollen, Jonathan L. Haines, Y. Liang, and Donald R. McLachlan

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Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management, John P. Weaver and Marc Fisher

Publications from 1993

Antimicrobial prophylaxis after tick bites, David A. Drachman

New criteria for the diagnosis of vascular dementia: do we know enough yet, David A. Drachman

Overview of Geriatric Neurology, David A. Drachman and Laurie Barclay

Driving and Alzheimer's disease: the risk of crashes, David A. Drachman and Joan M. Swearer

The Selection of Drugs for the Treatment of Memory Disorders, David A. Drachman and Joan M. Swearer

Current Review of Cerebrovascular Disease, Marc Fisher and Julien Bogousslavsky

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Evolving toward effective therapy for acute ischemic stroke, Marc Fisher and Julien Bogousslavsky

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Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A, Marc Fisher, Gregory M. Plante, and Elizabeth M. Doyle

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Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles, Carol F. Lippa, James E. Hamos, Thomas W. Smith, Donna Pulaski-Salo, and David A. Drachman

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Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus, Richard H. Melloni, Liza M. Hemmendinger, James E. Hamos, and Louis J. DeGennaro

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Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI, Kazuo Minematsu, Marc Fisher, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak

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Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats, Kazuo Minematsu, Marc Fisher, Limin Li, and Christopher H. Sotak

Electrical source analysis of auditory ERPs in medial temporal lobe amnestic syndrome, Brian F. O'Donnell, Ronald A. Cohen, Hiroto Hokama, B. Neil Cuffin, Carol F. Lippa, Martha E. Shenton, and David A. Drachman

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Hypermagnesemic pseudocoma, Marco A. Rizzo, Marc Fisher, and J. Paul Lock

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Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation, Kenneth M. Rosen, Bruce Martin Wentworth, Nadia Rosenthal, and Lydia Villa-Komaroff

Publications from 1992

A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group, K. L. Davis, Leon J. Thal, E. R. Gamzu, C. S. Davis, R. F. Woolson, S. I. Gracon, David A. Drachman, L. S. Schneider, P. J. Whitehouse, and T. M. Hoover

The etiology of Alzheimer's disease: the pathogenesis of dementia. The role of neurotoxins, David A. Drachman and Carol F. Lippa

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Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117, Marc Fisher and Margaret M. Arpano

Lacunar stroke: diagnosis, evaluation, and management, Marc Fisher and Kazuo Minematsu

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New magnetic resonance techniques for evaluating cerebrovascular disease, Marc Fisher, Christopher H. Sotak, Kazuo Minematsu, and Limin Li

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Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis, Scott H. Goodnight, John A. Cairns, Marc Fisher, and Garret A. FitzGerald

Alzheimer's disease and aging: effects on perforant pathway perikarya and synapses, Carol F. Lippa, James E. Hamos, D. Pulaski-Salo, Louis J. DeGennaro, and David A. Drachman

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A method for the direct measurement of mRNA in discrete regions of mammalian brain, Richard H. Melloni, Patricia S. Estes, David S. Howland, and Louis J. DeGennaro

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Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia, Kazuo Minematsu, L. Li, Marc Fisher, Christopher H. Sotak, Michael A. Davis, and M. S. Fiandaca

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Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats, Kazuo Minematsu, Limin Li, Christopher H. Sotak, Michael A. Davis, and Marc Fisher

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Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker, John J. Nunnari, Marc Fisher, and Stanley D. T. White

Incontinence and troublesome behaviors predict institutionalization in dementia, Brian F. O'Donnell, David A. Drachman, Heather J. Barnes, Karen E. Peterson, Joan M. Swearer, and Robert A. Lew

Active and passive P3 latency and psychometric performance: influence of age and individual differences, Brian F. O'Donnell, Susan Friedman, Joan M. Swearer, and David A. Drachman

Analysis of the prion protein gene in thalamic dementia, R. B. Petersen, M. Tabaton, L. Berg, B. Schrank, R. M. Torack, S. Leal, J. Julien, C. Vital, B. Deleplanque, W. W. Pendlebury, and David A. Drachman

Neuropsychological features of familial Alzheimer's disease, Joan M. Swearer, Brian F. O'Donnell, David A. Drachman, and Beatrice M. Woodward

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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs, Bruce Martin Wentworth, Christopher J. Rhodes, Bruno Schnetzler, David J. Gross, Phillippe A. Halban, and Lydia Villa-Komaroff

Publications from 1991

Meeting report: Antidementia drug assessment symposium, David A. Drachman

Section of geriatric neurology, David A. Drachman

Progressive External Ophthalmoplegia, David A. Drachman and David A. Chad

Atherosclerosis: cellular aspects and potential interventions, Marc Fisher

Ischemic cerebral vascular disease: an overview, Marc Fisher

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A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls, Marc Fisher, Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, D. A. Bergeron, Ronald A. Cohen, and James J. Hoogasian

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A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper, Marc Fisher, Peter H. Levine, Elizabeth M. Doyle, Margaret M. Arpano, and James J. Hoogasian

Expression of heat shock proteins in Alzheimer's disease, James E. Hamos, B. Oblas, D. Pulaski-Salo, W. J. Welch, D. G. Bole, and David A. Drachman

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Thrombosis in a congenitally bifurcated superior sagittal sinus, Mark A. Hosley, Marc Fisher, and James F. Lingley

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Positive- and negative-acting promoter sequences regulate cell type-specific expression of the rat synapsin I gene, David S. Howland, Liza M. Hemmendinger, Patrick D. Carroll, Patricia S. Estes, Richard H. Melloni, and Louis J. DeGennaro

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A highly polymorphic dinucleotide repeat on the proximal short arm of the human X chromosome: linkage mapping of the synapsin I/A-raf-1 genes, Cordula U. Kirchgessner, James A. Trofatter, Melanie M. Mahtani, Huntington F. Willard, and Louis J. DeGennaro

Primary progressive aphasia with focal neuronal achromasia, Carol F. Lippa, R. Cohen, Thomas W. Smith, and David A. Drachman

Publications from 1990

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Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei, Neil Aronin, Stephen M. Sagar, Frank R. Sharp, and William J. Schwartz

Dizziness and Vertigo: Common and Less Common Causes, David A. Drachman

The prognosis in Alzheimer's disease. 'How far' rather than 'how fast' best predicts the course, David A. Drachman, Brian F. O'Donnell, Robert A. Lew, and Joan M. Swearer

Alzheimer's disease, David A. Drachman and Joan M. Swearer

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A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes, Marc Fisher, Peter H. Levine, and Ronald A. Cohen

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Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis, Carlos S. Kase, Angela M. O'Neal, Marc Fisher, Gigi N. Girgis, and Joe I. Ordia

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First report of the congressionally appointed Advisory Panel on Alzheimer's Disease, Eric B. Larson, Robert Katzman, Elaine M. Brody, and David A. Drachman

The indusium griseum: is it involved in Alzheimer's disease, Carol F. Lippa, Thomas W. Smith, Umberto DeGirolami, and David A. Drachman

Active and Passive P3 Latency in Dementia: Relationship to Psychometric, Electroencephalographic, and Computed Tomographic Measures, Brian F. O'Donnell, Susan Friedman, Nancy K. Squires, Alan Maloon, David A. Drachman, and Joan M. Swearer

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Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model, David A. Phillips, Marc Fisher, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang

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Potent cytotoxicity of an antihuman transferrin receptor-ricin A-chain immunotoxin on human glioma cells in vitro, Lawrence D. Recht, Thomas W. Griffin, Vic Raso, and Ali R. Salimi

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Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains, William J. Schwartz and Pamela Zimmerman

Publications from 1989

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Amantadine treatment of fatigue associated with multiple sclerosis, Ronald A. Cohen and Marc Fisher

Clinical and research applications: An overview, David A. Drachman

Novel drug delivery systems: opportunities and caveats, David A. Drachman

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n-3 fatty acids and cellular aspects of atherosclerosis, Marc Fisher, Peter H. Levine, and Alexander Leaf

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Brain tumor presenting as an acute pure motor hemiparesis, Marc Fisher and Lawrence D. Recht

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Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis, Scott H. Goodnight, Marc Fisher, Garret A. FitzGerald, and Peter H. Levine

Synaptic loss in Alzheimer's disease and other dementias, James E. Hamos, Louis J. DeGennaro, and David A. Drachman

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Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis, Peter H. Levine, Marc Fisher, Peter B. Schneider, Richard H. Whitten, Bonnie H. Weiner, Ira S. Ockene, Brian F. Johnson, Mark H. Johnson, Elizabeth M. Doyle, and Patricia A. Riendeau