Title

The importance of carotid artery plaque disruption and hemorrhage

UMMS Affiliation

Department of Pathology; Department of Neurology

Publication Date

1987-10-01

Document Type

Article

Subjects

Arteriosclerosis; Carotid Artery Diseases; Endarterectomy; Hemorrhage; Humans; Myocardial Infarction; Thrombosis

Disciplines

Cardiology | Neurology

Abstract

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains uncertain. Analysis of carotid endarterectomy surgical specimens from symptomatic patients has suggested that primary intraplaque hemorrhage is the most important initiating event. Reanalysis of several recent series of carotid endarterectomy specimens demonstrated that plaque disruption (ulceration) occurs as frequently as plaque hemorrhage, and that both processes are significantly more frequent in symptomatic as compared with asymptomatic endarterectomy specimens. A review of the coronary artery pathology literature reveals that plaque disruption is commonly present in patients with acute fatal myocardial infarction. It is widely asserted that coronary artery plaque disruption leads to luminal thrombosis and intraplaque hemorrhage. A similar sequence of events may occur in symptomatic carotid arteries.

Source

Arch Neurol. 1987 Oct;44(10):1086-9.

Journal/Book/Conference Title

Archives of neurology

Related Resources

Link to article in PubMed

PubMed ID

3632384

Share

COinS