Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats
Department of Neurology
Analgesics, Non-Narcotic; Analysis of Variance; Animals; Catechols; Drug Interactions; Enzyme Inhibitors; Homocysteine; Hyperhomocysteinemia; Immunoassay; *Levodopa; Male; Nitriles; Nitrous Oxide; Random Allocation; Rats; Rats, Wistar
Nervous System Diseases | Neurology | Neuroscience and Neurobiology
BACKGROUND: This study investigated whether brief exposure to nitrous oxide (N(2)O) exacerbates levodopa-induced hyperhomocysteinemia, and if co-treatment with folate or entacapone could reduce total plasma homocysteine (tHcy) levels.
METHODS: Male Wistar rats (N=9 per group) were randomly treated with vehicle/N(2)O (GROUP 1), levodopa/nitrogen (group 2), levodopa/N(2)O (group 3), levodopa/N(2)O+folate (group 4), or levodopa/N(2)O+entacapone (group 5). tHcy was measured at 12 min, 4, 8, and 12 h after anesthesia.
RESULTS AND CONCLUSION: The combination of N(2)O-exposure and levodopa treatment significantly increased tHcy in rats. This hyperhomocysteinemia could be prevented by entacapone but not folate co-administration.
DOI of Published Version
Parkinsonism Relat Disord. 2007 Dec;13(8):524-7. Epub 2007 Jan 19. Link to article on publisher's site
Parkinsonism and related disorders
Henninger, Nils; Wang, Qi; Okun, Jurgen G.; Schwab, Stefan; and Krause, Martin, "Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats" (2007). Neurology Publications and Presentations. 449.