Title
Intravenous thrombolysis in a patient with known cavernous malformation: a first case report
UMMS Affiliation
Department of Neurology
Publication Date
2010-01-01
Document Type
Article
Subjects
Aged; Central Nervous System Neoplasms; Fibrinolytic Agents; Hemangioma, Cavernous, Central Nervous System; Humans; Male; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator
Disciplines
Emergency Medicine | Nervous System Diseases | Neurology
Abstract
The presence of a cerebral cavernous malformation (CM) is generally not regarded as an exclusion criterion to the use of intravenous tissue plasminogen activator (tPA). However, there is a conceivable risk of hemorrhaging with an intracerebral CM, which may dissuade clinicians from treating stroke patients with systemic tPA in the presence of a CM. The case of a 79-year-old man with acute ischemic stroke treated with systemic tPA in the setting of known CM is presented. The patient tolerated intravenous thrombolysis well and remained clinically stable throughout the observation period. This is the first reported case (to our knowledge) supporting the notion that systemic thrombolysis is safe in presence of a previously clinically silent CM.
DOI of Published Version
10.1016/j.ajem.2009.04.008
Source
Am J Emerg Med. 2010 Jan;28(1):117.e1-3. doi: 10.1016/j.ajem.2009.04.008. Link to article on publisher's site
Journal/Book/Conference Title
The American journal of emergency medicine
Related Resources
PubMed ID
20006229
Repository Citation
Henninger N, Ahmad N, Morris JG. (2010). Intravenous thrombolysis in a patient with known cavernous malformation: a first case report. Neurology Publications and Presentations. https://doi.org/10.1016/j.ajem.2009.04.008. Retrieved from https://escholarship.umassmed.edu/neuro_pp/446