Title

Intravenous thrombolysis in a patient with known cavernous malformation: a first case report

UMMS Affiliation

Department of Neurology

Publication Date

2010-01-01

Document Type

Article

Subjects

Aged; Central Nervous System Neoplasms; Fibrinolytic Agents; Hemangioma, Cavernous, Central Nervous System; Humans; Male; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator

Disciplines

Emergency Medicine | Nervous System Diseases | Neurology

Abstract

The presence of a cerebral cavernous malformation (CM) is generally not regarded as an exclusion criterion to the use of intravenous tissue plasminogen activator (tPA). However, there is a conceivable risk of hemorrhaging with an intracerebral CM, which may dissuade clinicians from treating stroke patients with systemic tPA in the presence of a CM. The case of a 79-year-old man with acute ischemic stroke treated with systemic tPA in the setting of known CM is presented. The patient tolerated intravenous thrombolysis well and remained clinically stable throughout the observation period. This is the first reported case (to our knowledge) supporting the notion that systemic thrombolysis is safe in presence of a previously clinically silent CM.

DOI of Published Version

10.1016/j.ajem.2009.04.008

Source

Am J Emerg Med. 2010 Jan;28(1):117.e1-3. doi: 10.1016/j.ajem.2009.04.008. Link to article on publisher's site

Journal/Book/Conference Title

The American journal of emergency medicine

Related Resources

Link to Article in PubMed

PubMed ID

20006229

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