Pre and Post-stroke Use of Statins Improves Stroke Outcome

UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Nervous System Diseases | Neurology


INTRODUCTION: Although there is sufficient evidence that HMG CoA Reductase Inhibitors reduce stroke recurrence in patients with or ischemic heart disease, it remains unclear whether they also improve outcomes given before or after stroke onset and whether such an effect is more robust with pre-stroke or post-stroke use of statins.

MATERIALS AND METHODS: We carried out a retrospective analysis of a large University Health Consortium Database. Patients with statin use before or after stroke onset were included in the analysis. Twenty patients discontinued statins after stroke onset. The outcome measures were discharge home or long-term care facility and/or death within 45 days.

RESULTS: Patients with prior statin use were more likely to be discharged home (1.67, CI 1.12-2.49), as were post stroke statin patients who had a more robust effect OR 2.63, CI 1.61-4.53).

CONCLUSIONS: Patients started on statins after stroke were more likely to be discharged home versus patients already on statins before stroke onset. However, both groups were also more likely to be discharged home than those patients not on statins.


HMG CoA reductase inhibitors, ischemic stroke, outcome

DOI of Published Version



Indian J Community Med. 2014 Oct;39(4):214-7. doi: 10.4103/0970-0218.143021. Link to article on publisher's site

Journal/Book/Conference Title

Indian journal of community medicine : official publication of Indian Association of Preventive and Social Medicine


Co-author Nils Henninger is a doctoral student in the Millennium PhD Program (MPP) in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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Link to Article in PubMed

PubMed ID