Endovascular acute ischemic stroke therapy: applying basic science to clinical decisions
Department of Neurology
Brain Ischemia; Endovascular Procedures; Humans; Stroke; Thrombolytic Therapy
Nervous System Diseases | Neurology
Excerpt: The interface between basic science and clinical medicine is a key to an enhanced understanding of disease pathophysiology and for developing novel therapies. The term translational research is applied to this interface and provides a framework for the interaction between basic scientists and clinicians. Ischemic stroke is a medical disorder for which translational research is particularly important, because of rapidly developing advances in understanding the cellular consequences of focal brain ischemia, the contributions of the neurovascular unit to disease pathophysiology, and the role of blood vessel abnormalities. These and other factors contribute to the development and evolution of ischemic brain injury when a thrombus impairs blood flow to a brain region. Reperfusion of these ischemic brain regions with thrombolytic drugs such as tissue plasminogen activator (tPA) or by deploying a mechanical device to remove the occluding thrombus is a logical approach to ischemic stroke therapy, because each method restores the availability of oxygen and glucose-rich blood flow that potentiate salvage of ischemic tissue destined for infarction.
DOI of Published Version
Neurology. 2012 Sep 25;79(13 Suppl 1):S42-3. Link to article on publisher's site
Fisher M. (2012). Endovascular acute ischemic stroke therapy: applying basic science to clinical decisions. Neurology Publications. https://doi.org/10.1212/WNL.0b013e3182695928. Retrieved from https://escholarship.umassmed.edu/neuro_pp/421