UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Endosomal Sorting Complexes Required for Transport; Neurons; Synapses; Neurodegenerative Diseases


Neurology | Neuroscience and Neurobiology


The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodegeneration. However, it remains largely elusive how ESCRTs act in post-mitotic neurons, a highly specialized cell type that requires dynamic changes in neuronal structures and signaling for proper function. This review focuses on our current understandings of the functions of ESCRTs in neuronal morphology, synaptic plasticity, and neurodegenerative diseases.

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Copyright © Experimental Neurobiology 2012. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Exp Neurobiol. 2012 Mar;21(1):9-15. Epub 2012 Feb 28. Link to article on publisher's site

Journal/Book/Conference Title

Experimental neurobiology

Related Resources

Link to Article in PubMed

PubMed ID