Title

Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model

UMMS Affiliation

Department of Radiology; Department of Pathology; Department of Neurology

Publication Date

1990-04-01

Document Type

Article

Subjects

Animals; Brain; Cerebral Angiography; Cerebral Hemorrhage; Cerebral Infarction; Cerebrovascular Disorders; Intracranial Embolism and Thrombosis; Peptide Fragments; Rabbits; Staphylococcal Protein A; Streptokinase; Time Factors; Tissue Plasminogen Activator

Disciplines

Nervous System Diseases | Neurology

Abstract

Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are under way. We evaluated two fibrinolytic agents, an analogue of tissue plasminogen activator (Fb-Fb-CF, the catalytic fragment of the tissue plasminogen activator molecule with a prolonged serum half-life, n = 10) and streptokinase (n = 7), in a rabbit model of embolic stroke. Both agents were given 3 hours after stroke onset, a time relevant to the clinical setting. Fb-Fb-CF was significantly better (p less than 0.04) than saline (n = 7) in restoring blood flow to previously occluded intracranial arteries, but streptokinase was ineffective. Neither fibrinolytic agent was associated with a substantial risk for intracerebral hemorrhagic side effects. Our study demonstrates that Fb-Fb-CF can safely and effectively reperfuse rabbit intracranial arteries 3 hours after occlusion, while streptokinase does not.

Source

Stroke. 1990 Apr;21(4):602-5.

Journal/Book/Conference Title

Stroke; a journal of cerebral circulation

Related Resources

Link to article in PubMed

PubMed ID

2109376

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