Dilemmas in the management of atrial fibrillation in chronic kidney disease

UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Anticoagulants; Atrial Fibrillation; Diabetes Mellitus; Diabetic Nephropathies; Hemorrhage; Humans; Incidence; Kidney Failure, Chronic; Obesity; Prevalence; Renal Dialysis; Stroke; Thromboembolism; United States


Neurology | Neuroscience and Neurobiology


Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality. Little attention has been paid to the problem of atrial fibrillation, although this arrhythmia is very frequent with a prevalence of 13 to 27% in patients on long-term hemodialysis. Because of the large number of pathophysiologic mechanisms involved, these patients have a high risk for both thromboembolic events and hemorrhagic complications. Stroke is a frequent complication in CKD: The US Renal Data System reports an incidence of 15.1% in hemodialysis patients compared with 9.6% in patients with other stages of CKD and 2.6% in a control cohort without CKD. The 2-yr mortality rates after stroke in these subgroups were 74, 55, and 28%, respectively. Although oral coumadin is the treatment of choice for atrial fibrillation, its use in patients with CKD is reported only in limited studies, all in hemodialysis patients, and is associated with a markedly increased rate of bleeding compared with patients without CKD. With regard to the high risk for stroke and the conflicting data about oral anticoagulation, an individualized stratification algorithm is presented based on relevant studies.

DOI of Published Version



J Am Soc Nephrol. 2009 Apr;20(4):705-11. Epub 2008 Dec 17. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Society of Nephrology : JASN

Related Resources

Link to Article in PubMed

PubMed ID