Title
Good laboratory practice: preventing introduction of bias at the bench
UMMS Affiliation
Department of Neurology
Publication Date
2008-08-16
Document Type
Article
Subjects
Animals; *Bias (Epidemiology); Conflict of Interest; Disease Models, Animal; Drug Industry; Humans; Random Allocation; Research Design; Research Support as Topic; Sample Size; Stroke; Treatment Outcome
Disciplines
Neurology | Neuroscience and Neurobiology
Abstract
BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.
CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
DOI of Published Version
10.1161/STROKEAHA.108.525386
Source
Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site
Journal/Book/Conference Title
Stroke; a journal of cerebral circulation
Related Resources
PubMed ID
18703798
Repository Citation
Macleod, Malcolm R.; Fisher, Marc; O'Collins, Victoria; Sena, Emily S.; Dirnagl, Ulrich; Bath, Philip M.W.; Buchan, Alistair; van der Worp, H. Bart; Traystman, Richard; Minematsu, Kazuo; Donnan, Geoffrey A.; and Howells, David W., "Good laboratory practice: preventing introduction of bias at the bench" (2008). Neurology Publications and Presentations. 368.
https://escholarship.umassmed.edu/neuro_pp/368