Good laboratory practice: preventing introduction of bias at the bench
Department of Neurology
Animals; *Bias (Epidemiology); Conflict of Interest; Disease Models, Animal; Drug Industry; Humans; Random Allocation; Research Design; Research Support as Topic; Sample Size; Stroke; Treatment Outcome
Neurology | Neuroscience and Neurobiology
BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.
CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
DOI of Published Version
Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site
Stroke; a journal of cerebral circulation
Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp H, Traystman R, Minematsu K, Donnan GA, Howells DW. (2008). Good laboratory practice: preventing introduction of bias at the bench. Neurology Publications. https://doi.org/10.1161/STROKEAHA.108.525386. Retrieved from https://escholarship.umassmed.edu/neuro_pp/368