Title
Good laboratory practice: preventing introduction of bias at the bench
UMMS Affiliation
Department of Neurology
Publication Date
2008-08-16
Document Type
Article
Subjects
Animals; *Bias (Epidemiology); Conflict of Interest; Disease Models, Animal; Drug Industry; Humans; Random Allocation; Research Design; Research Support as Topic; Sample Size; Stroke; Treatment Outcome
Disciplines
Neurology | Neuroscience and Neurobiology
Abstract
BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.
CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
DOI of Published Version
10.1161/STROKEAHA.108.525386
Source
Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site
Journal/Book/Conference Title
Stroke; a journal of cerebral circulation
Related Resources
PubMed ID
18703798
Repository Citation
Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp H, Traystman R, Minematsu K, Donnan GA, Howells DW. (2008). Good laboratory practice: preventing introduction of bias at the bench. Neurology Publications. https://doi.org/10.1161/STROKEAHA.108.525386. Retrieved from https://escholarship.umassmed.edu/neuro_pp/368