Title

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium

UMMS Affiliation

Department of Medicine; Department of Neurology; Brudnick Neuropsychiatric Research Institute

Publication Date

1994-07-01

Document Type

Article

Subjects

Aged; Alleles; Alzheimer Disease; Apolipoprotein C-II; Apolipoproteins C; Apolipoproteins E; Female; Gene Frequency; Humans; Jews; *Linkage Disequilibrium; Male; *Polymorphism, Genetic

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.

DOI of Published Version

10.1002/ana.410360118

Source

Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Ann Neurol. 1994 Jul;36(1):97-100. doi: 10.1002/ana.410360118. PMID: 8024269. Link to article on publisher's site

Journal/Book/Conference Title

Annals of neurology

Related Resources

Link to Article in PubMed

PubMed ID

8024269

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