Title
Memory decline in the aged: treatment with lecithin and physostigmine
UMMS Affiliation
Department of Neurology
Publication Date
1982-09-01
Document Type
Article
Subjects
Acetylcholine; Adult; Aged; Brain; Cognition; Double-Blind Method; Female; Humans; Learning; Male; Memory Disorders; Memory, Short-Term; Middle Aged; Phosphatidylcholines; Physostigmine; Psychological Tests; Receptors, Cholinergic; Synaptic Transmission
Disciplines
Neurology | Neuroscience and Neurobiology
Abstract
Normal aged subjects were given lecithin and placebo for 5 weeks each in a double-blind crossover study. Supraspan tests of memory and learning failed to show any significant changes as a result of these treatments. Addition of a single IV infusion of physostigmine did not improve performance. These findings neither support nor weaken the "cholinergic hypothesis" of cognitive impairment in aging and dementia, but they imply that simple cholinergic hypofunction is unlikely.
Source
Neurology. 1982 Sep;32(9):944-50.
Journal/Book/Conference Title
Neurology
Related Resources
PubMed ID
6287359
Repository Citation
Drachman, David A.; Glosser, Guila; Fleming, Peter D.; and Longenecker, R. Gerald, "Memory decline in the aged: treatment with lecithin and physostigmine" (1982). Neurology Publications and Presentations. 285.
https://escholarship.umassmed.edu/neuro_pp/285