Memory decline in the aged: treatment with lecithin and physostigmine
Department of Neurology
Acetylcholine; Adult; Aged; Brain; Cognition; Double-Blind Method; Female; Humans; Learning; Male; Memory Disorders; Memory, Short-Term; Middle Aged; Phosphatidylcholines; Physostigmine; Psychological Tests; Receptors, Cholinergic; Synaptic Transmission
Neurology | Neuroscience and Neurobiology
Normal aged subjects were given lecithin and placebo for 5 weeks each in a double-blind crossover study. Supraspan tests of memory and learning failed to show any significant changes as a result of these treatments. Addition of a single IV infusion of physostigmine did not improve performance. These findings neither support nor weaken the "cholinergic hypothesis" of cognitive impairment in aging and dementia, but they imply that simple cholinergic hypofunction is unlikely.
Neurology. 1982 Sep;32(9):944-50.
Drachman, David A.; Glosser, Guila; Fleming, Peter D.; and Longenecker, R. Gerald, "Memory decline in the aged: treatment with lecithin and physostigmine" (1982). Neurology Publications and Presentations. 285.