Title

Memory decline in the aged: treatment with lecithin and physostigmine

UMMS Affiliation

Department of Neurology

Publication Date

1982-09-01

Document Type

Article

Subjects

Acetylcholine; Adult; Aged; Brain; Cognition; Double-Blind Method; Female; Humans; Learning; Male; Memory Disorders; Memory, Short-Term; Middle Aged; Phosphatidylcholines; Physostigmine; Psychological Tests; Receptors, Cholinergic; Synaptic Transmission

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

Normal aged subjects were given lecithin and placebo for 5 weeks each in a double-blind crossover study. Supraspan tests of memory and learning failed to show any significant changes as a result of these treatments. Addition of a single IV infusion of physostigmine did not improve performance. These findings neither support nor weaken the "cholinergic hypothesis" of cognitive impairment in aging and dementia, but they imply that simple cholinergic hypofunction is unlikely.

Source

Neurology. 1982 Sep;32(9):944-50.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

6287359

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