Title

Motor neuron disease and paraproteinemia

UMMS Affiliation

Department of Neurology

Publication Date

1987-02-01

Document Type

Article

Subjects

Aged; Amyotrophic Lateral Sclerosis; Humans; Male; Middle Aged; *Motor Neurons; Muscular Atrophy; Neuromuscular Diseases; Paraproteinemias

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

We studied two patients with motor neuron disease and paraproteinemia. One had amyotrophic lateral sclerosis (ALS) and IgG lambda monoclonal gammopathy. The second had slowly progressive muscular atrophy and an IgM kappa paraprotein, followed by a biclonal gammopathy when an IgA kappa paraprotein appeared. Treatment with immunosuppressive agents and plasmapheresis lowered the serum concentration of the paraproteins. The ALS syndrome progressed despite therapy. The other patient improved, was stable for several years, but then deteriorated despite continued therapy.

Source

Neurology. 1987 Feb;37(2):335-7.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

3808319

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