Motor neuron disease and paraproteinemia
Department of Neurology
Aged; Amyotrophic Lateral Sclerosis; Humans; Male; Middle Aged; *Motor Neurons; Muscular Atrophy; Neuromuscular Diseases; Paraproteinemias
Neurology | Neuroscience and Neurobiology
We studied two patients with motor neuron disease and paraproteinemia. One had amyotrophic lateral sclerosis (ALS) and IgG lambda monoclonal gammopathy. The second had slowly progressive muscular atrophy and an IgM kappa paraprotein, followed by a biclonal gammopathy when an IgA kappa paraprotein appeared. Treatment with immunosuppressive agents and plasmapheresis lowered the serum concentration of the paraproteins. The ALS syndrome progressed despite therapy. The other patient improved, was stable for several years, but then deteriorated despite continued therapy.
Neurology. 1987 Feb;37(2):335-7.
Rudnicki SA, Chad DA, Drachman DA, Smith TW, Anwer UE, Levitan N. (1987). Motor neuron disease and paraproteinemia. Neurology Publications. Retrieved from https://escholarship.umassmed.edu/neuro_pp/266