Title

Cholinergic enhancement and REM sleep latency in the aged: lecithin does not reproduce physostigmine effect

UMMS Affiliation

Department of Neurology

Publication Date

1986-08-01

Document Type

Article

Subjects

Acetylcholine; Aged; Choline; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Physostigmine; Placebos; Sleep, REM

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

The administration of lecithin has failed to improve memory in aged or demented individuals. We studied the effect of lecithin on another cholinergic function, REM sleep latency. Intravenous doses of physostigmine shortened the latency to the first REM sleep period, but oral lecithin did not. In contrast to physostigmine, brain cholinergic function may not be enhanced by lecithin, which may explain why lecithin does not improve cognitive function.

Source

Neurology. 1986 Aug;36(8):1079-83.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

3736870

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