Title

Synaptic loss in Alzheimer's disease and other dementias

UMMS Affiliation

Department of Neurology

Publication Date

1989-03-01

Document Type

Article

Subjects

Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Child; Humans; Middle Aged; Neurofibrils; Synapses

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

The extent and location of neuronal losses necessary or sufficient to produce dementia in patients with Alzheimer's Disease (AD) is unknown. To approach this question, we studied synaptic terminals in postmortem brain tissue utilizing immunohistochemical techniques. We used antibodies against two proteins found in synaptic terminals--synapsin I and synaptophysin--as synaptic markers in the hippocampal complexes of eight patients with autopsy-proven AD and eight nondemented control subjects. Quantitative microscopy measured the regional density of synaptic staining. All AD patients showed a striking decrease in synaptic staining in the outer half of the molecular layer of the dentate gyrus compared with control brains, where the density of synaptic terminals was uniform throughout. In an additional patient with progressive degenerative dementia but without plaques or tangles on neuropathologic examination, similar depletion of synaptic staining was seen in the dentate gyrus. Quantitative densitometric analyses confirmed the focal decrease in synaptic staining in the outer half of the molecular layer in demented patients. We also found a slight increase in synaptic staining in the inner half of this layer.

Source

Neurology. 1989 Mar;39(3):355-61.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

2927643

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