Search for the familial Alzheimer's disease gene
Department of Neurology
Alzheimer Disease; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 21; Genetic Markers; Humans; Linkage (Genetics); Lod Score; Nerve Growth Factors; Polymorphism, Restriction Fragment Length
Neurology | Neuroscience and Neurobiology
The application of molecular genetic techniques to the study of autosomal dominantly inherited Familial Alzheimer's Disease may provide a means to determine the chromosomal location of the defective gene causing this form of Alzheimer's disease. Knowledge of the chromosomal location of the defective gene will provide a basis for isolating and characterizing this gene. Preliminary investigations indicate that several candidate genes can be excluded as the site of the defect. Current data also indicate that the defective gene does not reside close to random DNA markers on the distal portion of chromosome 21. Additional DNA markers on the proximal portion of chromosome 21 long arm are currently being investigated.
J Neural Transm Suppl. 1987;24:13-21.
Journal of neural transmission. Supplementum
St.George-Hyslop, Peter H.; Polinsky, Ronald J.; Haines, Jonathan L.; Nee, Linda; Tanzi, Rudolph E.; Conneally, P. Michael; Growdon, John; Myers, Richard H.; Pollen, Daniel A.; and Drachman, David A., "Search for the familial Alzheimer's disease gene" (1987). Neurology Publications and Presentations. 257.