The genetic defect causing familial Alzheimer's disease maps on chromosome 21
Department of Neurology
Alzheimer Disease; Chromosome Mapping; *Chromosomes, Human, Pair 21; Humans; Linkage (Genetics); Pedigree; Polymorphism, Restriction Fragment Length
Neurology | Neuroscience and Neurobiology
Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal dominant gene defect. The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21. The localization on chromosome 21 provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Isolation and characterization of the gene at this locus may yield new insights into the nature of the defect causing familial Alzheimer's disease and possibly, into the etiology of all forms of Alzheimer's disease.
Science. 1987 Feb 20;235(4791):885-90.
Science (New York, N.Y.)
St.George-Hyslop, Peter H.; Tanzi, Rudolph E.; Polinsky, Ronald J.; Haines, Jonathan L.; Nee, Linda; Watkins, Paul C.; Myers, Richard H.; Feldman, Robert G.; Pollen, Daniel A.; and Drachman, David A., "The genetic defect causing familial Alzheimer's disease maps on chromosome 21" (1987). Neurology Publications and Presentations. 216.