Title

The genetic defect causing familial Alzheimer's disease maps on chromosome 21

UMMS Affiliation

Department of Neurology

Publication Date

1987-02-20

Document Type

Article

Subjects

Alzheimer Disease; Chromosome Mapping; *Chromosomes, Human, Pair 21; Humans; Linkage (Genetics); Pedigree; Polymorphism, Restriction Fragment Length

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal dominant gene defect. The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21. The localization on chromosome 21 provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Isolation and characterization of the gene at this locus may yield new insights into the nature of the defect causing familial Alzheimer's disease and possibly, into the etiology of all forms of Alzheimer's disease.

Source

Science. 1987 Feb 20;235(4791):885-90.

Journal/Book/Conference Title

Science (New York, N.Y.)

Related Resources

Link to Article in PubMed

PubMed ID

2880399

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