Title

Primary progressive aphasia with focal neuronal achromasia

UMMS Affiliation

Department of Pathology; Department of Neurology

Publication Date

1991-06-01

Document Type

Article

Subjects

Aged; Aphasia; Brain; Brain Diseases; Humans; Male; Neuropsychological Tests; Tomography, X-Ray Computed

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

We describe the clinical, radiologic, neuropsychological, and neuropathologic features of a 69-year-old man with a 3-year history of progressive transcortical expressive aphasia. Neuropsychological testing showed progressive dysfunction of expressive language. Neuropathologic examination demonstrated focal cortical degeneration involving the left superior frontal gyrus, with swollen achromasic neurons and no evidence of Alzheimer's disease, Pick's disease, Creutzfeldt-Jakob disease, Lewybody disease, or other dementing disorders. This case adds to the known heterogeneity of the underlying pathology of patients with primary progressive aphasia.

Source

Neurology. 1991 Jun;41(6):882-6.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

2046934

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