Title

Expression of heat shock proteins in Alzheimer's disease

UMMS Affiliation

Department of Neurology

Publication Date

1991-03-01

Document Type

Article

Subjects

Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Carrier Proteins; Densitometry; Heat-Shock Proteins; Hippocampus; Humans; Immunohistochemistry; Limbic System; Middle Aged; *Molecular Chaperones; Reference Values

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

In an investigation of heat shock proteins (HSPs) in the brains of Alzheimer's disease (AD) patients and cognitively intact control subjects, we found that 2 HSPs, termed "HSP72" and "GRP78," underwent major changes in expression in AD. HSP72, which was present at very low levels in control brains, increased dramatically in AD patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. We hypothesize that HSP72 is induced as an early response to the formation of abnormal proteins, perhaps targeting them for proteolysis. In contrast, GRP78 increased in AD only in neurons that remained cytologically normal, especially in the CA3 subfield of the hippocampus and the deep layers of the entorhinal cortex. The increased expression of GRP78 within successfully surviving neurons suggests that this protein may protect such cells from AD-specific damage.

Source

Neurology. 1991 Mar;41(3):345-50.

Journal/Book/Conference Title

Neurology

Related Resources

Link to Article in PubMed

PubMed ID

2005999

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