Title
Histocompatibility (HL-A) factors in familial multiple sclerosis. Is multiple sclerosis susceptibility inherited via the HL-A chromosome
UMMS Affiliation
Department of Neurology
Publication Date
1976-06-01
Document Type
Article
Subjects
Adolescent; Adult; Age Factors; Child; Female; Genotype; HLA Antigens; Histocompatibility Antigens; Humans; Male; Middle Aged; Multiple Sclerosis; Pedigree
Disciplines
Neurology | Neuroscience and Neurobiology
Abstract
In order to study a possible hereditary factor leading to multiple sclerosis (MS) susceptibility, histocompatibility (HL-A) types were studied in families where two or more first-degree relatives had MS. Neither the inheritance of a particular parental HL-A chromosome, nor the occurrence of any specific HL-A antigens, could be shown to be necessary or sufficient for the development of MS in family members. The distribution of HL-A chromosomes was essentially the same for affected and unaffected family members. An excess of 3,7 haplotype and W21 antigen was demonstrated, both in affected patients and in unaffected family members, in equal proportions. We conclude that the HL-A chromosome has no direct causal relationship to MS susceptibility, although it may be indirectly associated by population stratification, maternal factors, or some other mechanism.
Source
Arch Neurol. 1976 Jun;33(6):406-13.
Journal/Book/Conference Title
Archives of neurology
Related Resources
PubMed ID
938264
Repository Citation
Drachman, David A.; Davison, William C.; and Mittal, Kamal K., "Histocompatibility (HL-A) factors in familial multiple sclerosis. Is multiple sclerosis susceptibility inherited via the HL-A chromosome" (1976). Neurology Publications and Presentations. 199.
https://escholarship.umassmed.edu/neuro_pp/199