Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk
Authors
Strohsnitter, William C.Savarese, Todd M.
Low, Hoi Pang
Chelmow, David P.
Lagiou, Pagona
Lambe, Mats
Edmiston, Kathryn L.
Liu, Qin
Baik, Inkyung
Noller, Kenneth L.
Adami, Hans-Olov
Trichopoulos, Dimitrios
Hsieh, Chung-Cheng
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDepartment of Medicine, Division of Hematology/Oncology
Department of Cancer Biology
Department of Obstetrics and Gynecology
Department of Neurology
Document Type
Journal ArticlePublication Date
2008-02-08Keywords
Antigens, CD38*Birth Weight
*Blood Cell Count
Female
Fetal Blood
Hematopoietic Stem Cells
Humans
Infant, Newborn
Male
Neoplasms
Risk
Cancer Biology
Hematology
Obstetrics and Gynecology
Oncology
Metadata
Show full item recordAbstract
We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38(-) cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with >or=3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk.Source
Br J Cancer. 2008 Feb 12;98(3):660-3. Epub 2008 Feb 5. Link to article on publisher's siteDOI
10.1038/sj.bjc.6604183Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37647PubMed ID
18256588Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6604183