Antihypertensive medications for risk reduction of first and recurrent ischemic stroke

UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Aged; Aged, 80 and over; Antihypertensive Agents; Brain Ischemia; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Primary Prevention; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Severity of Illness Index; Stroke; Survival Analysis; Treatment Outcome


Neurology | Neuroscience and Neurobiology


It is increasingly clear that even a small reduction in blood pressure results in a substantial risk reduction of vascular events including ischemic stroke. Recently, several comparative prospective trials of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers have demonstrated that, for equivalent reductions in blood pressure, these drugs may confer a greater effect on the prevention of primary and recurrent ischemic stroke compared with other antihypertensive medications. Given this information from prospective randomized trials, it appears that this class of drugs should be the first-line treatment for hypertension in patients at risk of a first or recurrent ischemic stroke. This review will critically assess the scientific basis and rationale of the use of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in primary and secondary stroke prevention.

DOI of Published Version



Expert Rev Cardiovasc Ther. 2004 Nov;2(6):867-76. Link to article on publisher's site

Journal/Book/Conference Title

Expert review of cardiovascular therapy

Related Resources

Link to article in PubMed

PubMed ID