Title

Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential

UMMS Affiliation

Department of Neurology; Department of Medicine, Division of Rheumatology

Publication Date

1986-12-01

Document Type

Article

Subjects

Dietary Fats; Fish Oils; Humans; Inflammation; Kinetics; Luminescent Measurements; Neutrophils; Superoxides

Disciplines

Immunology and Infectious Disease | Neurology

Abstract

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL inflammatory potential by measuring chemiluminescence and superoxide production before and after six weeks of daily cod liver oil ingestion by healthy volunteers. Phagocytosing PMNLs demonstrated a 27% decrease in chemiluminescence (P less than 0.05) and a 64% decrease in superoxide production (P less than 0.01), following the cod liver oil supplementation. Analysis of PMNL and platelet fatty acids revealed the appearance of eicosapentaenoic acid and a significant decrease in arachidonic acid in both types of cells.

Source

Inflammation. 1986 Dec;10(4):387-92.

Journal/Book/Conference Title

Inflammation

Related Resources

Link to article in PubMed

PubMed ID

3025092

Share

COinS