Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis
Department of Neurology
Humans; Hydrogen Peroxide; Monocytes; Multiple Sclerosis; Neutrophils; Superoxides
Nervous System Diseases | Neurology
Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating process. These inflammatory cells produce a variety of toxic oxygen metabolites which can mediate host tissue destruction. We measured production of two oxygen metabolites by monocytes and polymorphonuclear leukocytes in MS patients and controls. Stimulated monocytes produced significantly more hydrogen peroxide, superoxide, and chemiluminescence in the MS group than controls. The polymorphonuclear leukocyte, an inflammatory cell that appears to contribute little to MS demyelination, did not demonstrate increased production of toxic oxygen metabolites in the MS patients as compared to controls. These results suggest that blood monocytes in MS patients are primed to produce increased amounts of cytotoxic oxygen metabolites when exposed to inflammatory stimuli.
Inflammation. 1988 Apr;12(2):123-31.
Fisher M, Levine PH, Weiner BH, Vaudreuil CH, Natale AM, Johnson MH, Hoogasian JJ. (1988). Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis. Neurology Publications. Retrieved from https://escholarship.umassmed.edu/neuro_pp/142