Title
Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis
UMMS Affiliation
Department of Neurology
Publication Date
1988-04-01
Document Type
Article
Subjects
Humans; Hydrogen Peroxide; Monocytes; Multiple Sclerosis; Neutrophils; Superoxides
Disciplines
Nervous System Diseases | Neurology
Abstract
Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating process. These inflammatory cells produce a variety of toxic oxygen metabolites which can mediate host tissue destruction. We measured production of two oxygen metabolites by monocytes and polymorphonuclear leukocytes in MS patients and controls. Stimulated monocytes produced significantly more hydrogen peroxide, superoxide, and chemiluminescence in the MS group than controls. The polymorphonuclear leukocyte, an inflammatory cell that appears to contribute little to MS demyelination, did not demonstrate increased production of toxic oxygen metabolites in the MS patients as compared to controls. These results suggest that blood monocytes in MS patients are primed to produce increased amounts of cytotoxic oxygen metabolites when exposed to inflammatory stimuli.
Source
Inflammation. 1988 Apr;12(2):123-31.
Journal/Book/Conference Title
Inflammation
Related Resources
PubMed ID
2839419
Repository Citation
Fisher, Marc; Levine, Peter H.; Weiner, Bonnie H.; Vaudreuil, Christine H.; Natale, Anita M.; Johnson, Mark H.; and Hoogasian, James J., "Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis" (1988). Neurology Publications and Presentations. 142.
https://escholarship.umassmed.edu/neuro_pp/142